An?s

Related Terms

4-Ethylbenzaldehyde, 4-(3-methyloxiran-2-yl)phenyl 2-methylbutanoate, 4-(6-methylbicyclo[4.1.0]hept-2-en-7-yl)butan-2-one, 7-(4-(2-propenyl)phenylangelate), 12-(4-(3-methyloxiranyl)phenyltiglate), 17-(4-methoxy-2-(3-methyloxiranyl)phenyl isobutyrate), 18-(4-methoxy-2-(3-methyloxiranyl)phenylangelate), 21-(epoxy pseudoisoeugenol-2-methylbutyrate), acetaldehyde, alpha-himachalene, alpha-pinene, alpha-terpineol, alpha-tocopherols, alpha-zingiberene, aluminum, anace, anason, anethole, aneys, anice, anis (Spanish), anisaldehyde, aniseed (Anisum vulgare), anise oil, anise seed, anisi, anisic acid, Anisi fructus, Anisi vulgaris, anison (Greek), anissame, anisu, anisum (Latin), anisun, anisur, anis vert (French), anisyl alcohol, anny, annyle, anysum (Arabic), Apiaceae (family), apigenin 7-glucoside, ar-curcumene, ascorbic acid, bergapten, beta-bisabolene, beta-D-glucopyranosides, beta-pinene, beta-sitosterol, beta-tocopherols, boron, caffeic acid, calcium, camphene, chlorogenic acid, choline, chromium, cis-pseudoisoeugenyl 2-methylbutyrate, cobalt, copper, coumarins, d-carvone, delta-tocopherols, dianethole, estragole, eugenol, fiber, flavonoids, fructus Anisi (anise), fructus Anisi vulgaris, fruto de anis (Spanish), furfural, gamma-himachalene, graines d'anis (French), hydroquinone, imperatorin, iron, isoorientin, isovitexin, Kolorex?, lead, limonene, linalool, luteolin 7-glucoside, luteolin glycoside, magnesium, manganese, mannitol, methylchavicol, methyl syringate 4-O-beta-D-glucopyranoside, molybdenum, mononorsesquiterpenoids, myristicin, neophytadiene, nickel, p-anisaldehyde, p-cresol, phellandrene, phosphorus, photoanethole, Pimpinella anisetum, Pimpinella anisum spp., p-methoxybenzaldehyde, polyacetylenes, potassium, pristane, propenylphenols, pseudoisoeugenols, quercetin 3-glucuronide, rutin, sabene, saunf, sconio, scopoletin, semi d'aniso (Italian), seselin, sesquinorsesquiterpenoids, silicon, simiente de anis (Spanish), sompf, souf, squalene, stigmasterol, sweet Alice, sweet cumin, t-anethole, trans-anethole, trans-pseudoisoeugenyl 2-methylbutyrate, trinorsesquiterpenoids, tut-te-see-hau (native American), umbelliferon, zinc.

Background

Anise, a native to the eastern Mediterranean, is one of the oldest known spice plants. It is used for both medicinal purposes and for food. It is a member of the Apiaceae family, which includes carrot, parsley, dill, fennel, coriander, cumin, and caraway.
The Greek name anison and the Latin name anisum were derived from the early Arabic name anysum. Evidence suggests that anise was used in Egypt as early as 1500 B.C. The Romans used anise-spiced cakes to aid digestion after heavy meals. The oil of anise, which has a strong licorice flavor, is mixed with wine to form the liqueur anisette. Oil of anise also found in raki, a Turkish alcoholic beverage, and ouzo, a Greek alcoholic beverage.
Anise is used as a spice in cooking. Medicinally it is used to promote digestion and to increase urine flow. Anise oil is used in flavoring artificial licorice candies, cough lozenges, and syrups.
Anise is used in Europe to aid cancer treatment. In Mexico, Turkey, and China, it is used as a carminative (relieves intestinal gas) and galactagogue (stimulates breast milk production). Elsewhere, it is used to induce abortion and to treat respiratory illnesses, such as asthma, bronchitis, and cough. In combination with other herbs, anise has been used to treat head lice infestation. Anise is recognized by the U.S. Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS).

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


A water extract of a mixture of eight herbs (anise, black seed, caraway, cardamom, chamomile, fennel, licorice, and saffron) has demonstrated beneficial effects in patients with allergic asthma. Further studies on the effect of anise alone are needed before a conclusion may be made.

 C


A water extract of a mixture of eight herbs (anise, black seed, caraway, cardamom, chamomile, fennel, licorice, and saffron) has demonstrated beneficial effects in patients with allergic asthma. Further studies on the effect of anise alone are needed before a conclusion may be made.

 C


A combination of saffron, celery seed, and anise helped reduce menstrual pain. Additional studies on the effects of anise alone are needed before a conclusion may be made.

 C


A combination of saffron, celery seed, and anise helped reduce menstrual pain. Additional studies on the effects of anise alone are needed before a conclusion may be made.

 C


A combination of coconut oil and anise oil, with or without ylang ylang oil, has been used to treat head lice infestation. Further research on the effect of anise alone is needed before a conclusion may be made.

 C


A combination of coconut oil and anise oil, with or without ylang ylang oil, has been used to treat head lice infestation. Further research on the effect of anise alone is needed before a conclusion may be made.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
For colic, 10-30 grains of bruised, lightly ground or powdered seeds steeped in distilled hot water have been taken by mouth in "wine glassful" doses. Four to 20 drops of anise essential oil on sugar has also been taken by mouth.
As a digestive aid, essence of aniseed in hot water has been taken by mouth at bedtime.
For respiratory ailments, tea made by steeping anise seeds in hot water has been taken by mouth.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Anise may increase the risk of bleeding when taken with drugs that also increase the risk of bleeding. Examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin?) or heparin, antiplatelet drugs such as clopidogrel (Plavix?), and nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin?, Advil?) or naproxen (Naprosyn?, Aleve?).
Anise may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased or decreased in the blood and may cause increased or decreased effects or potentially serious adverse reactions. Patients using any medications should check the package insert and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
Anise may cause changes in blood pressure. Caution is advised in patients taking drugs that affect blood pressure.
Aniseed oil has been shown to increase glucose absorption in early study. Caution is advised when using medications that may lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional. Medication adjustments may be necessary.
Many anise containing beverages contain alcohol and may cause nausea or vomiting when taken with metronidazole (Flagyl?) or disulfiram (Antabuse?).
Because anise contains estrogen-like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.
Anise may also interact with agents that increase urine flow (diuretics), alkaloids, antiaging agents, antiarthritis agents, antibiotics, anticancer agents, antifungals, antihistamines, anti-inflammatories, antiprotozoals, antiseizure agents, antispasmodic agents, antivirals, bronchodilators, cholesterol- and triglyceride-lowering agents, cholinesterase inhibitors, drugs that affect GABA, fertility agents, gastrointestinal agents, hormonal agents, immunosuppressants, iron salts, muscle relaxants, neurological agents, or pain relievers.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

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