C?tone de framboise

Related Terms

2-Deoxyribose-5-phosphate aldolase (DERA), 2-hydroxy-4-[(3S)-3-hydroxybutyl]phenyl-beta-d-glucopyranoside, 2-hydroxy-5-[(3S)-3-hydroxybutyl]phenyl-beta-d-glucopyranoside, (2S)-4-(3,4-dihydroxyphenyl)-2-butanol, (2S)-4-(4-hydroxyphenyl)-2-butanol, (2S)-4-(4-hydroxyphenyl)but-2-yl-beta-d-glucopyranoside, 3,4-dimethoxyphenylpropanoids, 4-[(3S)-3-hydroxybutyl]phenyl-beta-d-glucopyranoside, 4-[4-(beta-d-glucopyranosyloxy)phenyl]-2-butanone, 4-(4-hydroxyphenyl) butan-2-one, 4-(4'-hydroxyphenyl)-2-butanone, 4-(4-hydroxyphenyl)-but-3-ene-2-one, 4-(4-hydroxyphenyl)-butan-2-one, 4-(4-hydroxyphenyl)butanone-2, 4-hydroxybenzalacetone, 4-hydroxybenzaldehyde, 4-hydroxybenzylidene acetone, 4-(para-hydroxyphenyl)-2-butanone, 4-(p-hydroxyphenyl)-2-butanone, acetone, Actinidia arguta, carbinols, cetona de frambuesa (Spanish), c?tone de framboise (French), Corps 112, Corps N-112, formic acid 4-(3-oxobutyl) phenyl ester, frambinone, kiwi fruit, oxanone, oxyphenylone, phenylbutanone raspberry ketone, p-hydroxybenzylacetone, p-hydroxyphenyl-2-butanone, p-hydroxyphenylpropanoids, rasketone, raspberry ketone formate, raspberry ketones, raspberry ketone/zingerone synthase-1 (RZS1), rastone, red raspberry fruit, red raspberry ketone, rheosmin, RK, RKF, Rubus idaeus, Rubus idaeus ketone.

Background

Raspberry ketone is a compound that is found in red raspberry fruits. It is responsible for the fruity aroma of raspberries, and it is often used as a fragrance and flavoring agent for cosmetics, perfumes, foods, and beverages. Although it is mostly found in raspberries, raspberry ketone has also been found in kiwifruit.
Natural raspberry ketone is one of the most expensive yet popular flavoring agents in the food industry. However, because finding raspberry ketone in its natural form may be difficult, its synthetic preparation has been explored.
There is some scientific evidence that suggests that raspberry ketone may improve the skin, promote hair growth and weight loss, and treat obesity. However, more research is needed to confirm the effects of raspberry ketone for any health-related purposes.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Early research suggests that raspberry ketone may promote hair growth in people who have hair loss. However, there is not enough available evidence, and more studies are needed in this area.

 C


Early research suggests that raspberry ketone may promote hair growth in people who have hair loss. However, there is not enough available evidence, and more studies are needed in this area.

 C


Early research has shown that raspberry ketone increases cheek skin elasticity. Although the results are promising, further research is needed before firm conclusions may be made.

 C


Early research has shown that raspberry ketone increases cheek skin elasticity. Although the results are promising, further research is needed before firm conclusions may be made.

 C


Early research suggests that raspberry ketone may promote weight loss and treat obesity. However, high-quality studies are needed before any conclusions may be made.

 C


Early research suggests that raspberry ketone may promote weight loss and treat obesity. However, high-quality studies are needed before any conclusions may be made.

 C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (18 years and older)
To promote weight loss and treat obesity, a single dose of 100 milligrams of raspberry ketone has been taken by mouth 30 minutes before a high fat meal.
To treat hair loss, a solution of 0.01% raspberry ketone has been applied to the skin once daily for five months.
To improve the appearance of skin, a solution of 0.01% raspberry ketone has been applied to the face once daily for 14 days.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Raspberry ketone may decrease the risk of bleeding when taken with drugs that increase the risk of bleeding, such as warfarin.
Raspberry ketone may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Raspberry ketone may also interact with agents that may block androgen receptor activity, agents that may regulate heart rate, agents that may treat liver disorders, agents that may treat skin disorders, anticancer agents, anti-inflammatory agents, cholesterol-lowering agents, hormonal agents, stimulants, and weight loss agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Beekwilder, J, van der Meer, IM, Sibbesen, O, et al. Microbial production of natural raspberry ketone. Biotechnol.J 2007;2(10):1270-1279.
Feron, G, Mauvais, G, Martin, F, et al. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35.
Harada, N, Okajima, K, Narimatsu, N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm.IGF.Res 2008;18(4):335-344.
Jang, EB, Casana-Giner, V, and Oliver, JE. Field captures of wild melon fly (Diptera: Tephritidae) with an improved male attractant, raspberry ketone formate. J Econ.Entomol. 2007;100(4):1124-1128.
Keng-Hong, T and Nishida, R. Synomone or kairomone?--Bulbophyllum apertum flower releases raspberry ketone to attract Bactrocera fruit flies. J Chem.Ecol. 2005;31(3):497-507.
Koeduka, T, Watanabe, B, Suzuki, S, et al. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108.
Lin, CH, Ding, HY, Kuo, SY, et al. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835.
Morimoto, C, Satoh, Y, Hara, M, et al. Anti-obese action of raspberry ketone. Life Sci. 5-27-2005;77(2):194-204.
Ogawa, Y, Akamatsu, M, Hotta, Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg.Med Chem.Lett. 4-1-2010;20(7):2111-2114.
Park, KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76(15):1654-1658.
Pedapudi, S, Chin, CK, and Pedersen, H. Production and elicitation of benzalacetone and the raspberry ketone in cell suspension cultures of Rubus idaeus. Biotechnol.Prog. 2000;16(3):346-349.
Shimoda, K, Harada, T, Hamada, H, et al. Biotransformation of raspberry ketone and zingerone by cultured cells of Phytolacca americana. Phytochemistry 2007;68(4):487-492.
Ushiki, M, Ikemoto, T, and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
Wang, L, Meng, X, and Zhang, F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15(5):495-503.
Zorn, H, Fischer-Zorn, M, and Berger, RG. A labeling study to elucidate the biosynthesis of 4-(4-hydroxyphenyl)-butan-2-one (raspberry ketone) by Nidula niveo-tomentosa. Appl.Environ.Microbiol. 2003;69(1):367-372.