Kinetin

Related Terms

Cytokinins, furfural, furfuryladenine, hyaluronidase, isopentenyladenine (IPA), kinerase, kinesin-I, kinetin, kinetin riboside.

Background

Kinetin is a chemical analogue of cytokinins, a class of plant hormones that promotes cell division. Kinetin is found in both plants and animals.
Scientific studies have investigated whether kinetin might help lower side effects associated with cataract surgery, aid in the treatment of Meniere's disease or decrease eye blood pressure. Currently, there is not enough scientific evidence to support any of these uses.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Side effects of cataract surgery may include pain, infection, swelling, bleeding, or retinal detachment. The use of kinetin during cataract surgery may lower adverse effects associated with cataracts. More research is needed in this area.

 C


Side effects of cataract surgery may include pain, infection, swelling, bleeding, or retinal detachment. The use of kinetin during cataract surgery may lower adverse effects associated with cataracts. More research is needed in this area.

 C


Meniere's disease is a disorder of the inner ear, which causes hearing loss, ringing in the ear, and the sensation that one's surroundings are spinning. Kinetin may be beneficial for patients with Meniere's disease. However, additional study is needed in this area.

C


Meniere's disease is a disorder of the inner ear, which causes hearing loss, ringing in the ear, and the sensation that one's surroundings are spinning. Kinetin may be beneficial for patients with Meniere's disease. However, additional study is needed in this area.

C


Kinetin may decrease blood pressure in the eye, although currently there is insufficient available evidence to draw a strong conclusion.

C


Kinetin may decrease blood pressure in the eye, although currently there is insufficient available evidence to draw a strong conclusion.

C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)

Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

Adults (over 18 years old)
There is no proven safe or effective dose for kinetin in adults.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Interactions

Interactions with Drugs
Kinetin may have antioxidant effects. Use cautiously in patients taking antioxidants due to possible additive effects.
Kinetin may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, blood thinners such as warfarin (Coumadin?) or heparin, antiplatelet drugs such as clopidogrel (Plavix?), and nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin?, Advil?) or naproxen (Naprosyn?, Aleve?).
Kinetin may inhibit cell growth, induce apoptosis, and stimulate cell differentiation. Use cautiously in patients with cancer or taking anticancer agents.

Attribution

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography

Adunka O, Moustaklis E, Weber A, et al. Labyrinth anesthesia--a forgotten but practical treatment option in Meniere's disease. ORL J Otorhinolaryngol.Relat Spec. 2003;65(2):84-90.
Barciszewski J, Mielcarek M, Stobiecki M, et al. Identification of 6-furfuryladenine (kinetin) in human urine. Biochem Biophys Res Commun. 12-9-2000;279(1):69-73.
Barciszewski J, Siboska GE, Pedersen BO, et al. Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA. Biochem Biophys Res Commun. 9-18-1997;238(2):317-319.
Glaser DA, Rogers C. Topical and systemic therapies for the aging face. Facial.Plast.Surg Clin North Am 2001;9(2):189-96, vii.
Griffaut B, Bos R, Maurizis JC, et al. Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. Int J Biol Macromol. 2004;34(4):271-275.
Hipkiss AR. On the "struggle between chemistry and biology during aging"--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention. Biogerontology. 2001;2(3):173-178. .
Honma Y, Ishii Y. Differentiation of human myeloid leukemia cells by plant redifferentiation-inducing hormones. Leuk.Lymphoma 2002;43(9):1729-1735.
Hsiao G, Shen MY, Lin KH, et al. Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo. Eur J Pharmacol 4-4-2003;465(3):281-287.
Ishii Y, Hori Y, Sakai S, et al. Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ. 2002;13(1):19-26.
Ishii Y, Kasukabe T, Honma Y. Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim.Biophys Acta 9-10-2005;1745(2):156-165.
Ishii Y, Sakai S, Honma Y. Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA. Biochim.Biophys Acta 12-7-2003;1643(1-3):11-24.
Kligman D. Cosmeceuticals. Dermatol Clin 2000;18(4):609-615.
Olsen A, Siboska GE, Clark B F, et al. N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Commun. 11-19-1999;265(2):499-502.
Sheu JR, Hsiao G, Shen MY, et al. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196.
Slaugenhaupt SA, Mull J, Leyne M, et al. Rescue of a human mRNA splicing defect by the plant cytokinin kinetin. Hum.Mol.Genet. 2-15-2004;13(4):429-436.