5,7-Dihydroxyflavone

Chrysin/Drug Interactions:

  • AntibioticsAntibiotics: In vitro, chrysin demonstrated antibacterial effects against Streptococcus sobrinus, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Streptococcus sobrinus, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Micrococcus luteus, and Enterobacter aerogenes (5; 4; 46). Chrysin resulted in a dose-dependent increase (up to 60%) in uptake of cefixime in vitro (80). It was postulated that chrysin could improve the bioavailability of cefixime.
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Chrysin has been reported to inhibit platelet aggregation in vitro (39; 7; 8; 9). Theoretically, concurrent use of chrysin with anticoagulant or antiplatelet agents may increase the risk of bleeding.
  • AntihypertensivesAntihypertensives: According to laboratory research, chrysin may exert vasorelaxant effects and lower blood pressure (7). Theoretically, concurrent use of chrysin and antihypertensive agents may have additive blood pressure-lowering effects and increase the risk of hypotension.
  • AntineoplasticsAntineoplastics: In a clinical study, researchers proposed that chrysin might reduce irinotecan (CPT-11) induced diarrhea (52). Chrysin has also been reported to synergistically enhance the effect of the antineoplastic agent epirubicin in vitro (42). In animal research, chrysin administered with topotecan increased the bioavailability of the antineoplastic agent topotecan (41).
  • Cytochrome P450-metabolized agentsCytochrome P450-metabolized agents: Preliminary evidence indicates that chrysin may inhibit or induce CYP1A enzymes (71; 72; 22; 73; 74; 75).
  • Drugs that may lower seizure thresholdDrugs that may lower seizure threshold: In animal research, chrysin prevented the expression of tonic-clonic seizures induced by pentylenetetrazol (6).
  • Hormonal agentsHormonal agents: In laboratory research, chrysin has displayed antiestrogen activity (11; 1; 47; 70; 12). In vitro, chrysin has been shown to inhibit aromatase, an enzyme that converts testosterone to estrogen (1; 47).
  • PhotosensitizersPhotosensitizers: In animal research, an oral combination product containing chrysin, quercetin, and a green tea phenol extract was found to reduce the damaging effect of UV radiation (69).

    • Chrysin/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: In vitro, chrysin demonstrated antibacterial effects against Streptococcus sobrinus, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Streptococcus sobrinus, Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Micrococcus luteus, and Enterobacter aerogenes (5; 4; 46).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Chrysin has been reported to inhibit platelet aggregation in vitro (39; 7; 8; 9). Theoretically, concurrent use of chrysin with anticoagulant or antiplatelet agents may increase the risk of bleeding.
  • AntineoplasticsAntineoplastics: In a clinical study, researchers proposed that chrysin might reduce irinotecan (CPT-11)-induced diarrhea (52). Chrysin has also been reported to synergistically enhance the effect of the antineoplastic agent epirubicin in vitro (42). In animal research, chrysin administered with topotecan increased the bioavailability of the antineoplastic agent topotecan (41).
  • Cytochrome P450-metabolized agentsCytochrome P450-metabolized agents: Preliminary evidence indicates that chrysin may inhibit or induce CYP1A enzymes (71; 72; 22; 73; 74; 75)
  • Hormonal agentsHormonal agents: In laboratory research, chrysin has displayed antiestrogen activity (11; 1; 47; 70; 12). In vitro, chrysin has been shown to inhibit aromatase, an enzyme that converts testosterone to estrogen (1; 47).
  • HypotensivesHypotensives: According to laboratory research, chrysin may exert vasorelaxant effects and lower blood pressure (7). Theoretically, concurrent use of chrysin and antihypertensive agents may have additive blood pressure-lowering effects and increase the risk of hypotension.
  • PhotosensitizersPhotosensitizers: In animal research, an oral combination product containing chrysin, quercetin, and a green tea phenol extract was found to reduce the damaging effect of UV radiation (69).
  • ResveratrolResveratrol: It has been suggested that chrysin may potentiate the effects of resveratrol by inhibiting hepatic and duodenal sulfation (81).
  • Seizure threshold-lowering agentsSeizure threshold-lowering agents: In animal research, chrysin prevented the expression of tonic-clonic seizures induced by pentylenetetrazol (6).

    • Chrysin/Food Interactions:

  • Insufficient available evidence.

    • Chrysin/Laboratory Interactions:

  • BilirubinBilirubin: In vitro studies have suggested that chrysin can lower bilirubin levels (61; 62).
  • Blood pressureBlood pressure: According to laboratory research, chrysin may lower blood pressure (7).
  • Hormone panelHormone panel: In laboratory research, chrysin has displayed antiestrogen activity (11; 1; 47; 70; 12). In vitro, chrysin has been shown to inhibit aromatase, an enzyme that converts testosterone to estrogen (1; 47). Human studies evaluating chrysin alone or in combination with other agents have reported mixed results on testosterone levels (49; 48; 27)