5-N-ethylglutamine
Theanine/Drug Interactions:
AntihypertensivesAntihypertensives: Theanine has been shown to lower blood pressure in animals (36; 37) and humans (22). Antineoplastic agentsAntineoplastic agents: In animal and in vitro studies, theanine enhanced the antitumor activity of some anticancer agents, including Adriamycin?, cisplatin, doxorubicin, idarubicin, and pirarubicin; enhanced the inhibitory effect on tumor growth; and increased the concentration of the anticancer drug in the tumor (26; 13; 10; 27; 28; 11; 29; 30; 31; 32; 33; 34). CaffeineCaffeine: In animal study, theanine demonstrated an antagonistic effect on caffeine's stimulatory action (24). Drugs that affect GABADrugs that affect GABA: In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Dopamine agonistsDopamine agonists: In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39).Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Dopamine antagonistsDopamine antagonists: In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39).Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). ImmunosuppressantsImmunosuppressants: In vitro, theanine demonstrated that it may help the body's immune system response when fighting infection by boosting the disease-fighting capacity of gamma delta T-cells (2). Norepinephrine-dopamine reuptake inhibitorsNorepinephrine-dopamine reuptake inhibitors: In animal hypertension model, theanine decreased norepinephrine levels (40). In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39).Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Neurologic agentsNeurologic agents: In animal studies of brain ischemia, theanine may offer neuroprotective effects based on its mechanism of action (41; 42; 43; 44; 19; 45). Theanine may have inhibitory effects at AMPA receptors, which are the most common receptor in the nervous system, but available evidence is lacking (46). Psychoactive agentsPsychoactive agents: In humans, theanine has psychoactive properties as evidenced by reductions in mental and physical stress and the production of feelings of relaxation (47; 40; 35). Acute doses of L-theanine may alter electroencephalographic (EEG) readings in a manner suggestive of increased alertness and attention (48; 47; 49). Selective serotonin reuptake inhibitorsSelective serotonin reuptake inhibitors: In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). In rats, theanine has reported to reduce brain serotonin concentrations (50). Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Serotonin-norepinephrine reuptake inhibitorsSerotonin-norepinephrine reuptake inhibitors: In animal hypertension model, theanine decreased norepinephrine levels (40). In animal study, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). In rats, theanine has reported to reduce brain serotonin concentrations (50). Theanine is speculated to increase the level of serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Theanine/Herb/Supplement Interactions:
Antineoplastic herbs and supplementsAntineoplastic herbs and supplements: In animal and in vitro studies, theanine enhanced the antitumor activity of some anticancer agents including Adriamycin?, cisplatin, doxorubicin, idarubicin, and pirarubicin, it enhanced the inhibitory effect on tumor growth, and increased the of the anticancer drug in the tumor (26; 13; 10; 27; 28; 11; 29; 30; 31; 32; 33; 34). CaffeineCaffeine: In animal research, theanine demonstrated an antagonistic effect on caffeine's stimulatory action (24). Dopamine agonistsDopamine agonists: In animal research, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). Theanine is speculated to increase serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Dopamine antagonistsDopamine antagonists: In animal research, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39).Theanine is speculated to increase serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). HypotensivesHypotensives: Theanine has been shown to lower blood pressure in animals (36; 37) and humans (22). ImmunomodulatorsImmunomodulators: In vitro,. theanine demonstrated that it may help the body's immune system response when fighting infection by boosting the disease-fighting capacity of gamma-delta T cells (2). Neurologic agentsNeurologic agents: Based on animal studies of brain ischemia, theanine may offer neuroprotective effects based on its mechanism of action (41; 42; 43; 44; 19; 45). Theanine may have inhibitory effects at AMPA receptors, which are the most common receptor in the nervous system, but further evidence is unavailable (46). In animal research, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). Theanine is speculated to increase serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Animal studies found that theanine significantly lowered levels of 5-hydroxyindole in the brain and may inhibit glutamic acid excitotoxicity (6; 23). Psychoactive herbs and supplementsPsychoactive herbs and supplements: In humans, theanine has psychoactive properties, as evidenced by reductions in mental and physical stress and the production of feelings of relaxation (47; 40; 35). Acute doses of L-theanine may alter electroencephalographic (EEG) readings in a manner suggestive of increased alertness and attention (48; 47; 49). Selective serotonin reuptake inhibitorsSelective serotonin reuptake inhibitors: In animal research, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). In rats, theanine has been reported to reduce brain serotonin concentrations (50). Theanine is speculated to increase serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Theanine/Food Interactions:
Insufficient available evidence.Theanine/Lab Interactions:
Blood pressureBlood pressure: Theanine has been shown to lower blood pressure in animals (36; 37) and humans (22). NeurotransmittersNeurotransmitters: In animal research, theanine enhanced synthesis of neurotransmitters during a nerve maturing period (39). Theanine is speculated to increase serotonin, dopamine, and gamma-aminobutyric acid (GABA) levels (23). Animal studies found that theanine significantly lowered levels of 5-hydroxyindole in the brain and may inhibit glutamic acid excitotoxicity (6; 23). NorepinephrineNorepinephrine: In an animal hypertension model, theanine decreased norepinephrine levels (40). SerotoninSerotonin: In rats, theanine has been reported to reduce brain serotonin concentrations (50). T cellsT cells: In vitro, theanine has been reported to increase human gamma-delta T cell proliferation (2).