Ackee

Ackee/Drug Interactions:

  • Antidiabetic agentsAntidiabetic agents: Ackee may interact with diabetes medication because toxic hypoglycemic syndrome after ingesting ackee has been reported in humans (4; 6). Hypoglycin A also induced a fall in blood glucose in rats (30).
  • Methylene blueMethylene blue: Based on animal evidence, methylene blue may act as an antidote for ackee poisoning if given within one hour of poisoning (17).

    • Ackee/Herb/Supplement Interactions:

  • HypoglycemicsHypoglycemics: Ackee may interact with hypoglycemic/hyperglycemic herbs because toxic hypoglycemic syndrome after ingesting ackee has been reported in humans (4; 6). Hypoglycin A also induced a fall in blood glucose in rats (30).

    • Ackee/Food Interactions:

  • Insufficient available evidence.

    • Ackee/Lab Interactions:

  • GeneralGeneral: Ackee may affect blood glucose, blood electrolytes, renal function, liver function, ammonaemia, coagulation tests, lactate and arterial pH. Ackee may affect medium-chain fatty acid levels in the urine. At autopsy massive liver steatosis is observed (15).
  • Alkaline phosphateAlkaline phosphate: Changes in blood levels may occur with ackee ingestion (21).
  • ALTALT: Changes in blood levels may occur with ackee ingestion (21).
  • Aspartate aminotransferaseAspartate aminotransferase: Decreased levels have been observed in rats (23).
  • ASTAST: Changes in blood levels may occur with ackee ingestion (21).
  • BilirubinBilirubin: Changes in blood levels may occur with ackee ingestion (21). Although there have also been reports of ackee use without resultant changes in bilirubin levels. (23).
  • Cell countsCell counts: Intraperitoneal administration of the lipid portion of the unripe ackee arillus (oil) resulted in marked neutropenia and increased platelets without anemia in rats (23).
  • Dicarboxylic acidDicarboxylic acid: Concentrations of dicarboxylic acid were 4-200 times higher in urine as compared with controls (9).
  • GlucoseGlucose: No changes in glucose were observed in rats (23). Hypoglycin A induced a fall in blood glucose in rats (30). Toxic hypoglycemic syndrome has been reported in humans (4; 6).
  • SodiumSodium: Decreased levels in rats (23).
  • UreaUrea: Decreased levels in rats (23).