Agrimonia eupatoria

Agrimony/Drug Interactions:

  • AnticoagulantsAnticoagulants: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • Antidiabetic agentsAntidiabetic agents: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with anti-diabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.
  • Antihypertensive drugsAntihypertensive drugs: Hypotensive effects in anaesthetized cats have been documented for Agrimony extract given by intravenous injection; blood pressure was lowered by more than 40% (1). Therefore, it is possible that the hypotensive effect may be additive with drugs used to treat hypertension. Excessive doses of agrimony might cause hypotension, interfering with therapy for hypertension or hypotension.
  • EstrogensEstrogens: Agrimony may be used to treat symptoms of menopause along with other herbs so it may be likely that it contains estrogenic-like component (6). Therefore, it should not be used in patients on some form of hormone-replacement therapy.
  • Nephrotoxic drugsNephrotoxic drugs: Since agrimony contains up to 21% tannins, chronic ingestion may result in nephrotoxicity.

    • Agrimony/Herb/Supplement Interactions:

  • AnticoagulantsAnticoagulants: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • HypoglycemicsHypoglycemics: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with antidiabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.
  • HypotensivesHypotensives: Hypotensive effects in anaesthetized cats have been documented for agrimony extract given by intravenous injection; blood pressure was lowered by more than 40% (1). Therefore, it is possible that the hypotensive effect may be additive with drugs used to treat hypertension. Excessive doses of agrimony might cause hypotension, interfering with therapy for hypertension or hypotension.
  • Hormonal herbsHormonal herbs: Agrimony may be used to treat symptoms of menopause along with other herbs so it may be likely that it contains estrogenic-like component (6). Therefore, it should not be used in patients on some form of hormone-replacement therapy.
  • Nephrotoxic herbsNephrotoxic herbs: Since agrimony contains up to 21% tannins, chronic ingestion may result in nephrotoxicity.

    • Agrimony/Food Interactions:

  • Insufficient available evidence.

    • Agrimony/Lab Interactions:

  • Coagulation panelCoagulation panel: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • Serum glucoseSerum glucose: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with anti-diabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.