Albizia

Albizia/Drug Interactions:

  • Antimalarial agentsAntimalarial agents: Based on in vivo animal studies, Albizia may have antimalarial effects and a synergistic interaction with chloroquine (14).
  • AntibioticsAntibiotics: Based on in vitro and human study, Albizia may have antibacterial effects (25; 22; 6). However, the effects of Albizia with antibacterial agents are not well understood.
  • Anticonvulsant agentsAnticonvulsant agents: In animal study, Albizia has been shown to protect against maximum electric shock, electrical kindling, and pentylenetetrazole-induced convulsions (23). However, the effects of Albizia with anticonvulsant agents are not well understood.
  • Antidepressant agentsAntidepressant agents: In animal study, Albizia has been shown to increase serotonin levels (21). Theoretically, concurrent use of Albizia with antidepressants may increase the risk of serotonin syndrome.
  • AntihistaminesAntihistamines: In invitro and invivo studies, chloroform, methanol, and water extracts of bark and leaves of Albizia lebbeck displayed significant mast-cell-stabilization activity, similar to that of chromoglycate (26). However, the effects of Albizia with antihistamines are not well understood.
  • Antineoplastic agentsAntineoplastic agents: In in vitro studies, Albizia has been shown to induce apoptosis and may possess antiproliferative effects (27; 28; 29; 30; 31; 10; 32; 33; 34). However, the effects of Albizia with antineoplastic agents are not well understood.
  • Anti-inflammatory agentsAnti-inflammatory agents: In animal studies, Albizia, in combination with six other herbs, showed an inhibitory effect against paw edema and carrageenan-induced acute inflammation (1). However, the effects of Albizia with anti-inflammatory agents are not well understood.
  • CNS depressantsCNS depressants: Based on animal study, the flowers of Albizia julibrissin may have sedative effects (16). Theoretically, concurrent use of Albizia and CNS depressants may cause additive sedation.
  • Dopamine agonistsDopamine agonists: In animal study, a saponin-containing fraction from the extract of dried leaves of Albizia was shown to decrease brain concentrations of dopamine (21). Theoretically, Albizia may alter the effects of dopamine agonists.
  • Drugs that affect GABADrugs that affect GABA: In animal study, a saponin-containing fraction from the extract of dried leaves of Albizia was shown to decrease brain concentrations of GABA (21).
  • Fertility agentsFertility agents: Albizia has been shown to prevent ovulation and reduce sperm motility and sperm density, based on animal study (17; 18; 19; 20). Theoretically, Albizia may alter or interfere with the effects of fertility agents.
  • ImmunosuppressantsImmunosuppressants: Based on animal study, the bark of Albizia lebbeck (Sirisha) may have immunopotentiating effects, as demonstrated by the ability to increase serum antibody titres (9). Theoretically, Albizia may alter the effects of immunosuppressants.
  • Mast cell stabilizers, inhaledMast cell stabilizers, inhaled: In invitro and invivo studies, chloroform, methanol, and water extracts of bark and leaves of Albizia lebbeck displayed significant mast-cell-stabilization activity, similar to that of chromoglycate (26). The effects of Albizia with mast cell stabilizers are not well understood.

    • Albizia/Herb/Supplement Interactions:

  • AnthelminticsAnthelmintics: Based on in vivo animal studies, Albizia may have antimalarial effects and a synergistic interaction with chloroquine (14).
  • AntibacterialsAntibacterials: Based on in vitro and human study, Albizia may have antibacterial effects (25; 22; 6). However, the effects of Albizia with antibacterial agents are not well understood.
  • AnticonvulsantsAnticonvulsants: In animal study, Albizia has been shown to protect against maximum electric shock, electrical kindling, and pentylenetetrazole-induced convulsions (23). However, the effects of Albizia with anticonvulsant agents are not well understood.
  • Antidepressant agents, selective serotonin reuptake inhibitors (SSRIs)Antidepressant agents, selective serotonin reuptake inhibitors (SSRIs): In animal study, Albizia has been shown to increase serotonin levels (21). Theoretically, concurrent use of Albizia with antidepressants may increase the risk of serotonin syndrome.
  • AntihistaminesAntihistamines: In invitro and invivo studies, chloroform, methanol, and water extracts of bark and leaves of Albizia lebbeck displayed significant mast-cell-stabilization activity, similar to that of chromoglycate (26). However, the effects of Albizia with antihistamines are not well understood.
  • Anti-inflammatory herbsAnti-inflammatory herbs: In animal studies, Albizia, in combination with six other herbs, showed an inhibitory effect against paw edema and carrageenan-induced acute inflammation (1). However, the effects of Albizia with anti-inflammatory agents are not well understood.
  • AntineoplasticsAntineoplastics: In in vitro studies, Albizia has been shown to induce apoposis and may possess antiproliferative effects (27; 28; 29; 30; 31; 10; 32; 33; 34). However, the effects of Albizia with antineoplastic agents are not well understood.
  • AntioxidantsAntioxidants: In in vitro study, Albizia, in combination with six other herbs, has been shown to exert scavenging activities toward free radicals (7).
  • Dopamine agonistsDopamine agonists: In animal study, a saponin-containing fraction from the extract of dried leaves of Albizia was shown to decrease brain concentrations of dopamine (21). Theoretically, Albizia may alter the effects of dopamine agonists.
  • Fertility agentsFertility agents: Albizia has been shown to prevent ovulation and reduce sperm motility and sperm density, based on animal study (17; 18; 19; 20). Theoretically, Albizia may alter or interfere with the effects of fertility agents.
  • Herbs and supplements that affect GABAHerbs and supplements that affect GABA: In animal study, a saponin-containing fraction from the extract of dried leaves of Albizia was shown to decrease brain concentrations of GABA (21).
  • ImmunosuppressantsImmunosuppressants: Based on animal study, the bark of Albizia lebbeck (Sirisha) may have immunopotentiating effects, as demonstrated by the ability to increase serum antibody titres (9). Theoretically, Albizia may alter the effects of immunosuppressants.
  • Sedative herbs and supplementsSedative herbs and supplements: Based on animal study, the flowers of Albizia julibrissin may have sedative effects (16). Theoretically, concurrent use of Albizia and sedative agents may cause additive drowsiness.

    • Albizia/Food Interactions:

  • Insufficient available evidence.

    • Albizia/Lab Interactions:

  • DNA testingDNA testing: Alkaloid isolates from Albizia amara have been shown to interact with DNA in vitro (35).
  • Fertility testingFertility testing: Albizia has been shown to prevent ovulation and reduce sperm motility and sperm density, based on animal study (17; 18; 19; 20).
  • Immune panelImmune panel: Based on animal study, the bark of Albizia lebbeck (Sirisha) increased serum antibody titres (9).