Artemisia annua

Sweet annie/Drug Interactions:

  • Antiangiogenic drugsAntiangiogenic drugs: Based on in vivo and in vitro studies, artesunate, a semi-synthetic derivative of artemisinin extracted from Artemisia annua, may inhibit angiogenesis (28).
  • AntibioticsAntibiotics: Based on an in vitro study, the essential oil of Artemisia annua aerial parts may inhibit bacterial growth (37).
  • AntifungalsAntifungals: Based on an in vitro study, the essential oil of Artemisia annua aerial parts may inhibit fungal growth (37).
  • Antimalarial agentsAntimalarial agents: Based on laboratory, animal, and clinical studies, Artemisia annua extracts may have antimalarial properties (45; 46; 42; 25; 26).
  • Antineoplastic agentsAntineoplastic agents: Based on several in vitro studies, Artemisia annua constituents, including artesunate, artemisinin, dihydroartemisinin, and quercetagetin 6,7,3',4'-tetramethyl ether, may have antineoplastic activity (29; 35; 31; 32; 30; 33).
  • AntioxidantsAntioxidants: Based on laboratory tests, the essential oil of Artemisia annua aerial parts may have antioxidant activity (37).
  • Cardiovascular agentsCardiovascular agents: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system and cardiovascular toxicities (40).
  • ChloroquineChloroquine: Based on a mouse study, a combination of Artemisia annua and chloroquine may be more effective in fever subsidence and disappearance of malarial symptoms than either substance alone (42). The high recrudescence rate in this therapy may be inhibited by combining with primaquine.
  • ImmunosuppressantsImmunosuppressants: Based on in vitro and in vivo studies, a water soluble derivative of artemisinin may have immunosuppressive activity (39).
  • Neurological agentsNeurological agents: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system toxicities (40).
  • PrimaquinePrimaquine: Based on a mouse study, a combination of Artemisia annua, chloroquine, and primaquine may inhibit recrudescence in Artemisia annua and chloroquine therapy (42).
  • QuinolinesQuinolines: Based on the conclusions of a review, artesunate may be incompatible with quinolines by virtue of proton transfer (41). Quinolines are aromatic organic bases synthesized or obtained from coal tar and used as food preservatives and in making antiseptics. These should not be confused with quinolones, which are a family of broad-spectrum antibiotics.
  • Sodium butyrateSodium butyrate: Based on in vitro studies, extracts from Artemisia annua and analogs of Artemisia annua constituents have been found to have anticancer properties, especially when combined with sodium butyrate (31).

    • Sweet annie/Herb/Supplement Interactions:

  • Antiangiogenic herbsAntiangiogenic herbs: Based on in vivo and in vitro studies, artesunate, a semi-synthetic derivative of artemisinin extracted from Artemisia annua, may inhibit angiogenesis (28).
  • AntibacterialsAntibacterials: Based on an in vitro study, the essential oil of Artemisia annua aerial parts may inhibit bacterial growth (37).
  • AntifungalsAntifungals: Based on an in vitro study, the essential oil of Artemisia annua aerial parts may inhibit fungal growth (37).
  • Antimalarial agentsAntimalarial agents: Based on laboratory, animal, and clinical studies, Artemisia annua extracts may have antimalarial properties (45; 46; 42; 25; 26).
  • AntineoplasticsAntineoplastics: Based on several in vitro studies, Artemisia annua constituents, including artesunate, artemisinin, dihydroartemisinin, and quercetagetin 6,7,3',4'-tetramethyl ether, may have antineoplastic activity activity (29; 35; 31; 32; 30; 33).
  • AntioxidantsAntioxidants: Based on laboratory tests, the essential oil of Artemisia annua aerial parts may have antioxidant activity (37).
  • Cardioactive herbsCardioactive herbs: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system and cardiovascular toxicities (40).
  • ImmunosuppressantsImmunosuppressants: Based on in vitro and in vivo studies, a water-soluble derivative of artemisinin may have immunosuppressive activity (39).
  • Neurological agentsNeurological agents: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system toxicities (40).

    • Sweet annie/Food Interactions:

  • Insufficient available evidence.

    • Sweet annie/Lab Interactions:

  • Cardiac-specific Troponin I and TCardiac-specific Troponin I and T: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system and cardiovascular toxicities (40).
  • Creatine kinaseCreatine kinase: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system and cardiovascular toxicities (40).
  • MyoglobinMyoglobin: Based on the toxicities found in a related species (Artemisia composita), Artemisiaannua may have potential central nervous system and cardiovascular toxicities (40).