Beta-hydroxy beta-methylbutyrate

Hydroxymethylbutyrate/Drug Interactions:

  • AntihypertensivesAntihypertensives: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
  • AntilipemicsAntilipemics: In human research, HMB supplementation lowered total and LDL cholesterol (2).
  • Antiobesity agentsAntiobesity agents: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18; 16).
  • Antiviral agentsAntiviral agents: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3).
  • ImmunosuppressantsImmunosuppressants: Based on human research, HMB supplementation may stimulate the immune system (2). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).

    • Hydroxymethylbutyrate/Herb/Supplement Interactions:

  • AntilipemicsAntilipemics: In human research, HMB supplementation lowered total and LDL cholesterol (2).
  • Antiobesity herbs and supplementsAntiobesity herbs and supplements: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18), particularly when used with creatine (16).
  • AntiviralsAntivirals: Human research has demonstrated a decrease in the HIV viral load with HMB/arginine/glutamine supplementation in patients with HIV (3).
  • ArginineArginine: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
  • Athletic performance enhancersAthletic performance enhancers: Based on findings from human research, HMB supplementation may have positive effects on exercise performance by increasing the onset of blood lactate accumulation (18).
  • CreatineCreatine: In human research, HMB supplementation has been found to increase fat loss and increase lean body mass (18), particularly when used with creatine (16).
  • GlutamineGlutamine: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
  • HypotensivesHypotensives: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
  • ImmunostimulantsImmunostimulants: In human research, HMB supplementation in combination with arginine and glutamine reduced HIV viral load (3). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).
  • ImmunosuppressantsImmunosuppressants: Based on human research, HMB supplementation may stimulate the immune system (2). In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).

    • Hydroxymethylbutyrate/Food Interactions:

  • SugarSugar: In human research, HMB absorption was slightly lower when consumed with glucose (19).

    • Hydroxymethylbutyrate/Lab Interactions:

  • Blood pressureBlood pressure: In human research, HMB supplementation reduced systolic blood pressure (diastolic blood pressure was unaffected) (2).
  • Blood urea nitrogen (BUN)tBlood urea nitrogen (BUN): In human research, HMB supplementation increased blood urea nitrogen (BUN) (15).
  • CortisolCortisol: In human research, HMB supplementation decreased cortisol levels (20).
  • Creatine kinaseCreatine kinase: In human research, HMB supplementation has been shown to prevent exercise-induced increases in creatine kinase (20; 10; 16; 21; 4; 1).
  • HIV viral loadHIV viral load: In human research, a combination of HMB, arginine, and glutamine decreased HIV viral load (3).
  • Lactate dehydrogenase (LDH)Lactate dehydrogenase (LDH): In humans, HMB supplementation decreased lactate dehydrogenase (LDH) (21).
  • Lipid profileLipid profile: In human research, HMB supplementation lowered total and LDL cholesterol (2).
  • Plasma ureaPlasma urea: In human research, HMB supplementation decreased plasma urea (16).
  • Red blood cellsRed blood cells: In human research, HMB supplementation increased red blood cells, including hemoglobin and hematocrit (15).
  • Urine urea nitrogenUrine urea nitrogen: In human research, HMB supplementation decreased urine urea nitrogen (16).
  • White blood cellsWhite blood cells: In human research, HMB supplementation increased basophils (10), lymphocytes, and eosinophils (15). In human research, a combination of HMB, arginine, and glutamine increased CD3 and CD8 cells (3).