Bridelia ferruginea
Bridelia species/Drug Interactions:
AntibioticsAntibiotics: In vitro, extracts from many species of Bridelia exhibited antibacterial activity (4; 6; 18; 12; 13; 5; 29; 14). Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In animal research, extracts of Bridelia ferruginea exhibited antithrombotic effects (17). Antidiabetic agentsAntidiabetic agents: According to secondary sources, Bridelia has been used traditionally for its potential antidiabetic effects. Mist bredina is a decoction prepared from Bridelia ferruginea that has purportedly been used for management of diabetes mellitus type 2. Clinical evidence for this therapy is lacking.AntidiarrhealsAntidiarrheals: In in vitro and animal research, extracts of Bridelia micrantha bark demonstrated antidiarrheal activity (19). AntifungalsAntifungals: In laboratory research, extracts of the stem bark of Bridelia retusa showed antifungal activity against Cladosporium cladosporioides at very low concentrations (7). AntihypertensivesAntihypertensives: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease in arterial pressure (24). Anti-inflammatory agentsAnti-inflammatory agents: Extracts from many species of Bridelia have exhibited anti-inflammatory activity in vitro and in animal studies (2; 9; 11; 10). Antimalarial agentsAntimalarial agents: In vitro, extracts of the root and stem of Bridelia cathartica caused a 50% inhibition of Plasmodium falciparum growth (20). EstrogensEstrogens: In animal and in vitro research, some constituents of the extracts of Bridelia ferruginea had estrogenic activity (25). Heart rate-regulating agentsHeart rate-regulating agents: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease in heart rate (24). ImmunomodulatorsImmunomodulators: Based on in vitro evidence, an extract from Bridelia ferruginea stem bark may dose-dependently inhibit the classical and the alternative pathways of the complement system (26). Uterotonic agentsUterotonic agents: In animal research, Bridelia atroviridis had a potent uterotonic action (28). Bridelia species/Herb/Supplement Interactions:
AntiarrhythmicsAntiarrhythmics: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease in heart rate (24). AntibacterialsAntibacterials: In vitro, extracts from many species of Bridelia exhibited antibacterial activity (4; 6; 18; 12; 13; 5; 29; 14). Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In animal research, extracts of Bridelia ferruginea exhibited antithrombotic effects (17). AntidiarrhealsAntidiarrheals: In in vitro and animal research, extracts of Bridelia micrantha bark demonstrated antidiarrheal activity (19). AntifungalsAntifungals: In laboratory research, extracts of the stem bark of Bridelia retusa showed antifungal activity against Cladosporium cladosporioides at very low concentrations (7). Anti-inflammatory herbsAnti-inflammatory herbs: Extracts from many species of Bridelia have exhibited anti-inflammatory activity in vitro and in animal studies (2; 9; 11; 10). Antimalarial herbs and supplementsAntimalarial herbs and supplements: In vitro, extracts of the root and stem of Bridelia cathartica caused a 50% inhibition of Plasmodium falciparum growth (20). AntioxidantsAntioxidants: In vitro, constituents of Bridelia ferruginea exhibited xanthine oxidase-inhibiting and superoxide-scavenging activity at micromolar concentrations (15). HypoglycemicsHypoglycemics: According to secondary sources, Bridelia has been used traditionally for its potential antidiabetic effects. Mist bredina is a decoction prepared from Bridelia ferruginea that has purportedly been used for management of diabetes mellitus type 2. Clinical evidence for this therapy is lacking.HypotensivesHypotensives: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease of arterial pressure (24). ImmunomodulatorsImmunomodulators: Based on in vitro evidence, an extract from Bridelia ferruginea stem bark may dose-dependently inhibit the classical and the alternative pathways of the complement system (26). IronIron: The iron content in the root bark of Bridelia cathartica and its decoction (boiled extract) compared well with those found in edible leafy vegetables (3). Prominent iron contents of 35.69mg/100g were found in the root bark (30), a higher total iron content than the corresponding leaves and stem bark. The iron content of the decoctions prepared in the traditional way was low. PhytoestrogensPhytoestrogens: In animal and in vitro research, some constituents of the extracts of Bridelia ferruginea had estrogenic activity (25). Uterotonic herbs and supplementsUterotonic herbs and supplements: In animal research, Bridelia atroviridis had a potent uterotonic action (28). Bridelia species/Food Interactions:
Insufficient available evidence.Bridelia species/Lab Interactions:
Blood glucoseBlood glucose: According to secondary sources, Bridelia has been used traditionally for its potential antidiabetic effects. Mist bredina is a decoction prepared from Bridelia ferruginea that has purportedly been used for management of diabetes mellitus type 2. Clinical evidence for this therapy is lacking.Blood pressureBlood pressure: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease in arterial pressure (24). Coagulation panelCoagulation panel: In animal research, extracts of Bridelia ferruginea exhibited antithrombotic effects (17). Heart rateHeart rate: In animal research, preparations of the leaves of Bridelia atroviridis caused a decrease in heart rate (24). Iron levelsIron levels: The iron content in the root bark of Bridelia cathartica and its decoction (boiled extract) compared well with those found in edible leafy vegetables (3). Prominent iron contents of 35.69mg/100g were found in the root bark (30), a higher total iron content than the corresponding leaves and stem bark. The iron content of the decoctions prepared in the traditional way was low.