Bryonia alba

White bryony/Drug Interactions:

  • Antidiabetic agentsAntidiabetic agents: In animal research, the mechanism of action for the hypoglycemic effects of white bryony has been investigated (10). The research was concerned with the effects of trihydroxyoctadecadiene acids, a constituent of Bryonia alba, on the activity of glycogen phosphorylase (a- and b-forms), phosphoprotein phosphatase, and hexokinase in liver and muscle tissues. The regulating effect of trihydroxyoctadecadienoic acids from Bryonia alba, as well as the herb itself, on the glucose-fatty acid cycle and glucose levels in an alloxan diabetes model was discussed (8; 11). No further details are available at this time.
  • CorticosteroidsCorticosteroids: According to human research, Bryonia alba root extract may increase the concentration of cortisol in blood plasma (29). According to animal research, cucurbitacin R diglucoside, a constituent of Bryonia alba L. root, may alter production of corticosteroids (30).

    • White bryony/Herb/Supplement Interactions:

  • HypoglycemicsHypoglycemics: In animal research, the mechanism of action of hypoglycemic effects of white bryony has been investigated (10). The research was concerned with the effects of trihydroxyoctadecadiene acids, a constituent of Bryonia alba, on the activity of glycogen phosphorylase (a- and b-forms), phosphoprotein phosphatase, and hexokinase in liver and muscle tissues. The regulating effect of trihydroxyoctadecadienoic acids from Bryonia alba, as well as the herb itself, on the glucose-fatty acid cycle and glucose levels in an alloxan diabetes model was discussed (8; 11). No further details are available at this time.

    • White bryony/Food Interactions:

  • Insufficient available evidence.

    • White bryony/Lab Interactions:

  • CortisolCortisol: According to human research, Bryonia alba root extract may increase the concentration of cortisol in blood plasma (29). According to animal research, cucurbitacin R diglucoside, a constituent of Bryonia alba L. root, may alter production of corticosteroids (30).
  • EicosanoidsEicosanoids: According to animal and in vitro research, cucurbitacin R diglucoside, a constituent of Bryonia alba L. root may alter biosynthesis of eicosanoids in the adrenal cortex, as well as isolated adrenocortical cells, blood plasma, and leukocytes (30).
  • Lipid profileLipid profile: According to an animal diabetes model, trihydroxyoctadecadienoic acids, constituents of Bryonia alba, may restore disordered lipid metabolism (nonesterified fatty acid levels and membrane phospholipid fatty acid distribution) (9).
  • Nitric oxideNitric oxide: According to human research, Bryonia alba root extract may increase the concentration of nitric oxide in blood plasma (29).
  • Prostaglandin E2Prostaglandin E2: According to in vitro research, a standardized preparation of Bryonia C-18 carbon fatty acids may increase prostaglandin E2 release (9).
  • Thromboxane B2Thromboxane B2: Based on in vitro research, a standardized preparation of Bryonia C-18 carbon fatty acids may reduce thromboxane B2 generation (9).