Capers

Capers/Drug Interactions:

  • Antidiabetic agentsAntidiabetic agents: Based on ethnobotanical data, Capparis spinosa L. may have hypoglycemic effects (1).
  • Antifungal agentsAntifungal agents: In laboratory study, extracts of the aerial parts of Capparis spinosa exhibited antibacterial activity against Gram-positive and Gram-negative bacteria and antifungal activity (9).
  • AntihypertensivesAntihypertensives: Based on tradition, Capparis spinosa may have antihypertensive effects (4).
  • Anti-inflammatory agentsAnti-inflammatory agents: In in vitro study using human chondrocyte cultures, extracts of Capparis spinosa were shown to counter the effects of oxidative-inflammatory stress (4).
  • Antimicrobial agentsAntimicrobial agents: In laboratory study, extracts of the aerial parts of Capparis spinosa exhibited antibacterial activity against Gram-positive and Gram-negative bacteria and antifungal activity (9).
  • AntioxidantsAntioxidants: In in vitro study, extracts from flowering buds of Capparis spinosa exhibited significant antioxidant activity (2). In in vitro study using human chondrocyte cultures, extracts of Capparis spinosa were shown to counter the effects of oxidative-inflammatory stress (4).
  • AntiviralsAntivirals: In laboratory study, an extract of C. spinosa buds (CAP) was shown to interfere with herpes simplex virus type 2 (HSV-2) replication in human peripheral blood mononuclear cells (PBMCs) (5).
  • DiureticsDiuretics: Based on clinical study, capers may have diuretic effects; patients taking the combination product Liv-52?, containing Capparis spinosa, showed a significant reduction in ascites (p=0.032) (3).
  • ImmunomodulatorsImmunomodulators: Based on clinical and in vitro study, Capparis spinosa may have immunomodulating effects (3; 4).
  • ImmunosuppressantsImmunosuppressants: Based on clinical and in vitro study, Capparis spinosa may have immunomodulating effects (3; 4).
  • Iron-containing drugsIron-containing drugs: A commercially available preparation, Liv-52? (Himalayan Co. India) containing Capparis spinosa in combination with other constituents, contains iron, which may have an additive effect when taken with iron-containing drugs leading to iron overload.
  • Nonsteroidal anti-inflammatory agents (NSAIDs), COX 2Nonsteroidal anti-inflammatory agents (NSAIDs), COX 2: In in vitro study using human chondrocyte cultures, extracts of Capparis spinosa were shown to counter the effects of oxidative-inflammatory stress (4).
  • Photoprotective agentsPhotoprotective agents: In in vivo studies using healthy human volunteers, a topically applied extract of flowering buds of Capparis spinosa showed a significant photoprotective effect against UVB-induced skin damage (2).
  • Photosensitizing agentsPhotosensitizing agents: In in vivo studies using healthy human volunteers, a topically applied extract of flowering buds of Capparis spinosa showed a significant photoprotective effect against UVB-induced skin damage (2).

    • Capers/Herb/Supplement Interactions:

  • AntifungalsAntifungals: In laboratory study, extracts of the aerial parts of Capparis spinosa exhibited antibacterial activity against Gram-positive and Gram-negative bacteria and antifungal activity (9).
  • Anti-inflammatoriesAnti-inflammatories: In in vitro study using human chondrocyte cultures, extracts of Capparis spinosa were shown to counter the effects of oxidative-inflammatory stress (4).
  • AntimicrobialsAntimicrobials: In laboratory study, extracts of the aerial parts of Capparis spinosa exhibited antibacterial activity against gram-positive and gram-negative bacteria and antifungal activity (9).
  • AntioxidantsAntioxidants: In in vitro study, extracts from flowering buds of Capparis spinosa exhibited significant antioxidant activity (2). In in vitro study using human chondrocyte cultures, extracts of Capparis spinosa were shown to counter the effects of oxidative-inflammatory stress (4).
  • AntiviralsAntivirals: In laboratory study, an extract of C. spinosa buds (CAP) was shown to interfere with herpes simplex virus type 2 (HSV-2) replication in human peripheral blood mononuclear cells (PBMCs) (5).
  • DiureticsDiuretics: Based on clinical study, capers may have diuretic effects; patients taking the combination product Liv-52?, containing Capparis spinosa, showed a significant reduction in ascites (p=0.032) (3).
  • IronIron: A commercially available preparation, Liv-52? (Himalayan Co. India) containing Capparis spinosa in combination with other constituents, contains iron, which may have an additive effect when taken with iron-containing drugs leading to iron overload.
  • HypoglycemicsHypoglycemics: Based on ethnobotanical data, Capparis spinosa L. may have hypoglycemic effects (1).
  • HypotensivesHypotensives: Based on tradition, Capparis spinosa may have antihypertensive effects (4).
  • ImmunomodulatorsImmunomodulators: Based on clinical and in vitro study, Capparis spinosa may have immunomodulating effects (3; 4).
  • Photoprotective herbs and supplementsPhotoprotective herbs and supplements: In in vivo studies using healthy human volunteers, a topically applied extract of flowering buds of Capparis spinosa showed a significant photoprotective effect against UVB -induced skin damage (2).
  • Photosensitizing herbs and supplementsPhotosensitizing herbs and supplements: In in vivo studies using healthy human volunteers, topically applied extract of flowering buds of Capparis spinosa showed a significant photoprotective effect against UVB-induced skin damage (2).
  • QuercetinQuercetin: Extracts from flowering buds of Capparis spinosa are known to contain quercetin (4; 2).

    • Capers/Food Interactions:

  • Insufficient available evidence.

    • Capers/Lab Interactions:

  • Blood pressureBlood pressure: Based on tradition, Capparis spinosa may have antihypertensive effects (4).
  • Electrolyte levelsElectrolyte levels: Based on clinical study, capers may have diuretic effects; patients taking the combination product Liv-52?, containing Capparis spinosa, showed a significant reduction in ascites (p=0.032) (3).
  • ImmunoassayImmunoassay: Based on clinical and in vitro study, Capparis spinosa may have immunomodulating effects (3; 4).
  • Liver enzymesLiver enzymes: Capparis spinosa is one of several ingredients in a combination drug, Liv-52? (Himalayan Co. India), associated with improved liver cirrhosis outcomes in human clinical study (3) and thus may affect hepatic assays.
  • Serum glucoseSerum glucose: Based on ethnobotanical data, Capparis spinosa L. may have hypoglycemic effects (1).
  • Urine analysisUrine analysis: Based on clinical study, capers may have diuretic effects; patients taking the combination product Liv-52?, containing Capparis spinosa, showed significant reductions in ascites (p=0.032) (3).
  • Viral loadViral load: In laboratory study, an extract of C. spinosa buds (CAP) was shown to interfere with herpes simplex virus type 2 (HSV-2) replication in human peripheral blood mononuclear cells (PBMCs) (5).