Caprylic acid

Caprylic acid/Drug Interactions:

  • Albumin-bound agentsAlbumin-bound agents: Pharmaceutical-grade albumin solutions showed significantly lower drug-binding capacity vs. native human serum and sigma albumin (22). Using caprylic acid as a stabilizer in the manufacturing procedure seemed to be important. Theoretically, caprylic acid may alter the pharmacokinetics and therapeutic effects of drugs that are highly bound to albumin.
  • CarbarylCarbaryl: Caprylic acid inhibited the hydrolysis of carbaryl, a cholinesterase inhibiting insectide, by human serum albumin (HSA) (23). Sorgorb and colleagues theorized that albumin may be an important factor in the detoxification of carbaryl by the body. Theoretically, caprylic acid may increase susceptibility to carbaryl exposure and decrease the body's ability to clear carbaryl.
  • IndomethacinIndomethacin: Indomethacin can inhibit the cardiovascular effects of octanoic acid (24).
  • Inotropic agentsInotropic agents: Octanoic displays inotropic activity. As a result, arterial pressure and vascular resistance decrease, and cardiac output increases (24).
  • NimodipineNimodipine: The use of caprylic acid in a transdermal system increased the permeation of nimodipine across human cadaver skin at 24 hours (25).
  • Non-steroidal anti-inflammatory agentsNon-steroidal anti-inflammatory agents: Octanoic acid reduced retention of a several non-steroidal anti-inflammatory agents (NSAIAs). Results suggest a competitive displacement interaction takes place (26). Reduced capacity factors of (R)- and (S)-ketorolac consistent with displacement of drug from human serum albumin (HSA) binding sites resulted after the enclusion of octanoic acid in the column eluent (27).
  • PhenylbutazonePhenylbutazone: Phenylbutazone was competitively displaced from the the warfarin-azapropazone binding area (drug binding Site I) by high levels of octanoic acid (28).
  • WarfarinWarfarin: Warfarin was competitively displaced from the warfarin-azapropazone binding area (drug binding Site I) by high levels of octanoic acid (28).

    • Caprylic acid/Herb/Supplement Interactions:

  • Non-steroidal anti-inflammatory herbsNon-steroidal anti-inflammatory herbs: Octanoic acid reduced retention of a several non-steroidal anti-inflammatory agents (NSAIAs). Results suggest a competitive displacement interaction takes place (26). Reduced capacity factors of (R)- and (S)-ketorolac consistent with displacement of drug from human serum albumin (HSA) binding sites resulted after the enclusion of octanoic acid in the column eluent (27).

    • Caprylic acid/Food Interactions:

  • Insufficient available evidence.

    • Caprylic acid/Lab Interactions:

  • Coagulation panelCoagulation panel: Warfarin was competitively displaced from the warfarin-azapropazone binding area (drug binding Site I) by high levels of octanoic acid (28).