Carnosine

Carnosine/Drug Interactions:

  • AntihypertensivesAntihypertensives: Limited evidence from a review has indicated that carnosine may possess antihypertensive properties (26). Carnosine has also been shown to inhibit sympathetic innervation to the renal blood vessels in rats (29).
  • Anti-inflammatoriesAnti-inflammatories: According to a review, carnosine may have the ability to interact with lipid peroxidation products and active oxygen species and to prevent membrane damage (30). Carnosine has further been observed to suppress the secretion of inflammatory cytokines by intestinal epithelial cells that had been exposed to oxidative stress (31).
  • AntineoplasticsAntineoplastics: According to a review, limited evidence indicates that carnosine may have antineoplastic effects (26).
  • ImmunosuppressantsImmunosuppressants: According to a review, limited evidence indicates that carnosine may exhibit immunomodulatory activity (26).

    • Carnosine/Herb/Supplement Interactions:

  • Anti-inflammatoriesAnti-inflammatories: According to a review, carnosine may have the ability to interact with lipid peroxidation products and active oxygen species and to prevent membrane damage (30). Carnosine has further been observed to suppress the secretion of inflammatory cytokines by intestinal epithelial cells that had been exposed to oxidative stress (31).
  • AntineoplasticsAntineoplastics: According to a review, limited evidence indicates that carnosine may have antineoplastic effects (26).
  • AntioxidantsAntioxidants: According to a review, carnosine may be able to attenuate cellular oxidative stress and inhibit the intracellular formation of reactive oxygen and nitrogen species (9). According to another review, carnosine may delay cataract formation via antiglycation and other antioxidative activity (10).
  • HypotensivesHypotensives: Limited evidence from a review has indicated that carnosine may possess antihypertensive properties (26). Carnosine has also been shown to inhibit sympathetic innervation to the renal blood vessels in rats (29).
  • ImmunomodulatorsImmunomodulators: According to a review, limited evidence indicates that carnosine may exhibit immunomodulatory activity (26).
  • ZincZinc: According to a review, carnosine may alter zinc's ability to influence neuronal excitability and to exert neurotoxic effects in the olfactory system (32).

    • Carnosine/Food Interactions:

  • Insufficient available evidence.

    • Carnosine/Lab Interactions:

  • Blood 2,3-diphosphoglycerate levelsBlood 2,3-diphosphoglycerate levels: In human experimentation, a dietary supplement containing carnosine given for 3.5 days enhanced postexercise levels of whole blood 2,3-diphosphoglycerate (2,3-DPG) and the 2,3-DPG:Hb ratio (33).
  • Blood bicarbonate bufferingBlood bicarbonate buffering: In human research, oral supplementation with chicken breast extract, rich in carnosine, increased the contribution of the nonbicarbonate buffering system and decreased bicarbonate buffering action in blood (34).