Chlorella

Chlorella/Drug Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on the vitamin K content in chlorella and a case report of increased thrombotest values after ingestion of chlorella while on warfarin therapy, chlorella may interact with warfarin (24). Based on in vitro study, Chlorella pyrenoidosa may have strong hemagglutination activity (8).
  • AntihypertensivesAntihypertensives: In humans, chlorella decreased hypertension (10; 22).
  • Anti inflammatoriesAnti inflammatories: In vitro, chlorella powder had anti-inflammatory properties (2).
  • AntilipemicsAntilipemics: In humans, chlorella decreased cholesterol levels (10).
  • AntineoplasticsAntineoplastics: In mice and in vitro, chlorella demonstrated anticancer effects (4; 5; 3).
  • Dioxin-detoxifying drugsDioxin-detoxifying drugs: In humans, chlorella decreased dioxins levels in breast milk (9).
  • Heavy metal antagonists/chelating agentsHeavy metal antagonists/chelating agents: Chlorella may increase the fecal and urinary excretion of cadmium (7).
  • ImmunosuppressantsImmunosuppressants: In vitro, chlorella may have immunostimulating effects (11; 2; 12), although a clinical study by Halperin et al. did not find that Chlorella pyrenoidosa significantly increased antibodies after oral dietary supplementation and influenza vaccination (26).
  • PhotosensitizersPhotosensitizers: In humans, chlorella demonstrated photosensitizing effects (23). Chlorella may cause hyperpigmentation, dermatitis, or make a patient more sensitive to laser treatment.
  • VaccinesVaccines: Based on a clinical trial, ONC-107 (Respondin?) extracted from Chlorella pyrenoidosa cells may selectively boost antibody response to the influenza vaccine (11). However, another clinical study by Halperin et al. did not find that Chlorella pyrenoidosa significantly increased antibodies after oral dietary supplementation and influenza vaccination (26).
  • WarfarinWarfarin: Based on the vitamin K content in chlorella and a case report of increased thrombotest values after ingestion of chlorella while on warfarin therapy, chlorella may interact with warfarin (24).

    • Chlorella/Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on the vitamin K content in chlorella and a case report of increased thrombotest values after ingestion of chlorella while on warfarin therapy, chlorella may interact with warfarin (24). Based on in vitro study, Chlorella pyrenoidosa may have strong hemagglutination activity (8).
  • Anti inflammatoriesAnti inflammatories: In vitro, chlorella powder had anti-inflammatory properties (2).
  • AntilipemicsAntilipemics: In humans, chlorella decreased cholesterol levels (10).
  • AntineoplasticsAntineoplastics: In mice and in vitro, chlorella demonstrated anticancer effects (4; 5; 3).
  • AntioxidantsAntioxidants: In vitro, chlorella demonstrated antioxidant activity (3).
  • Dioxin-detoxifying herbsDioxin-detoxifying herbs: In humans, chlorella may decrease dioxins levels in breast milk (9).
  • Heavy metal antagonists/chelating agentsHeavy metal antagonists/chelating agents: Chlorella may increase the fecal and urinary excretion of cadmium (7).
  • HypotensivesHypotensives: In humans, chlorella decreased hypertension (10; 22).
  • ImmunosuppressantsImmunosuppressants: In vitro, chlorella may have immunostimulating effects (11; 2; 12), although a clinical study by Halperin et al. did not find that Chlorella pyrenoidosa significantly increased antibodies after oral dietary supplementation and influenza vaccination (26).
  • ManganeseManganese: In humans, chlorella contained 1.7mg of manganese in a daily dose and long-term ingestion may cause manganese-induced parkinsonism (16).
  • PhotosensitizersPhotosensitizers: In humans, chlorella demonstrated photosensitizing effects (23). Chlorella may cause hyperpigmentation, dermatitis, or make a patient more sensitive to laser treatment.
  • Vitamin KVitamin K: Chlorella has a high vitamin K content (24).

    • Chlorella/Food Interactions:

  • Vitamin K-containing foodsVitamin K-containing foods: Chlorella has a high vitamin K content (24).

    • Chlorella/Lab Interactions:

  • Antibody testsAntibody tests: Based on in vitro studies, chlorella may have immunostimulating effects (11; 2; 12), although a clinical study by Halperin et al. did not find that Chlorella pyrenoidosa significantly increased antibodies after oral dietary supplementation and influenza vaccination (26).
  • Dioxin levelsDioxin levels: Based on a clinical study, chlorella may decrease dioxins levels in breast milk (9).
  • INR/PTTINR/PTT: Based on the vitamin K content in chlorella and a case report of increased thrombotest values after ingestion of chlorella while on warfarin therapy, chlorella may interact with warfarin (24). Based on in vitro study, Chlorella pyrenoidosa may have strong hemagglutination (8).
  • Serum lipid levelsSerum lipid levels: Based on a clinical study in patients with hypertension, chlorella may decrease cholesterol levels (10).