Corydalis

Corydalis/Drug Interactions:

  • AnalgesicsAnalgesics: According to patient self-reports from clinical study, Corydalis yanhusuo and Angelicae dahuricae significantly decreased cold-induced pain intensity and the level at which pain was considered bothersome (11); a dose-related analgesic effect was also observed. According to human in vitro study, alkaloids from Corydalis dependently inhibited K(ATP) channel currents (11).
  • AntiarrhythmicsAntiarrhythmics: In human study, L-tetrahydropalmatine (rotundium), an alkaloid of Corydalis turtschaninovii, demonstrated positive antiarrhythmic effects in blocking calcium channels that were similar to other antiarrhythmics, including bepridil (6). Based on laboratory study, products of Corydalis sempervirens and Saccharomyces cerevisiae are predicted to adopt similar functions as Staphylococcus aureus nuclease (SNase) homologues, which have been shown to mediate single-stranded DNA binding (16).
  • AntibioticsAntibiotics: Corydalis has shown antibacterial effects in laboratory studies (9; 3; 5; 17).
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro study in human cancer cell lines, corydalis may have additive effects when taken with antineoplastic agents (12; 13).
  • Antiretroviral agentsAntiretroviral agents: In laboratory study, certain alkaloids isolated from Corydalis yanhusuo were shown to inhibit HIV-1 reverse transcriptase (14).
  • Cardiovascular agentsCardiovascular agents: Alkaloids derived from Corydalis yanhusuo have been studied experimentally for the treatment of premature systoles (arrhythmia) (7). In human study, L-tetrahydropalmatine (rotundium), an alkaloid of Corydalis turtschaninovii, demonstrated positive antiarrhythmic effects in blocking calcium channels that were similar to other antiarrhythmics, including bepridil (6). A decoction of Radix Salviae miltiorrhizae-Rhizoma Corydalis and nicotinic acid solution administered by iontophoresis to the precordium has been studied for the treatment of angina pectoris (8).
  • SedativesSedatives: Alkaloids derived from Corydalis saxicola, as well as Tetrahydropalmatine (THP) and its analogues (all of which are derived from Corydalis ambigua and various species of Stephania), have demonstrated tranquilizing and hypnotic effects and therefore may interact or augment the effects of sedative medications (10; 4).

    • Corydalis/Herb/Supplement Interactions:

  • AnalgesicsAnalgesics: According to patient self-reports from clinical study, Corydalis yanhusuo and Angelicae dahuricae significantly decreased cold-induced pain intensity and the level at which pain was considered bothersome (11); a dose-related analgesic effect was also observed. According to human in vitro study, alkaloids from Corydalis dependently inhibited K(ATP) channel currents (11).
  • AntiarrhythmicsAntiarrhythmics: In human study, L-tetrahydropalmatine (rotundium), an alkaloid of Corydalis turtschaninovii, demonstrated positive antiarrhythmic effects in blocking calcium channels that were similar to other anti-arrhythmics, including bepridil (6). Based on laboratory study, products of Corydalis sempervirens and Saccharomyces cerevisiae are predicted to adopt similar functions as Staphylococcus aureus nuclease (SNase) homologues, which have been shown to mediate single-stranded DNA binding (16).
  • AntibioticsAntibiotics: Corydalis has shown antibacterial effects in laboratory studies (9; 3; 5; 17).
  • AntineoplasticsAntineoplastics: Based on in vitro study in human cancer cell lines, corydalis may have additive effects when taken with antineoplastic agents (12; 13).
  • AntiviralsAntivirals: In laboratory study, certain alkaloids isolated from Corydalis yanhusuo were shown to inhibit HIV-1 reverse transcriptase (14).
  • Cardiovascular herbs and supplementsCardiovascular herbs and supplements: Alkaloids derived from Corydalis yanhusuo have been studied experimentally for the treatment of premature systoles (arrhythmia) (7). In human study, L-tetrahydropalmatine (rotundium), an alkaloid of Corydalis turtschaninovii, demonstrated positive antiarrhythmic effects in blocking calcium channels that were similar to other anti-arrhythmics, including bepridil (6). A decoction of Radix Salviae miltiorrhizae-Rhizoma Corydalis and nicotinic acid solution administered by iontophoresis to the precordium has been studied for the treatment of angina pectoris (8).
  • SedativesSedatives: Alkaloids derived from Corydalis saxicola, as well as Tetrahydropalmatine (THP) and its analogues (all of which are derived from Corydalis ambigua and various species of Stephania), have demonstrated tranquilizing and hypnotic effects and therefore may interact with or augment the effects of sedative medications (10; 4).

    • Corydalis/Food Interactions:

  • Tyramine-containing foodTyramine-containing food: Tyramine is a monoamine compound found in certain foods that can cause an increase in systolic blood pressure if ingested in large quantities. It is unknown if compounds such as berberine, isolated from Corydalis pallida, have cytotoxic effects (13) that may interact with food containing tyramine.

    • Corydalis/Lab Interactions:

  • Bacterial culturesBacterial cultures: Corydalis bungeana extracts showed activity against B. subtilis at 6.25mcg/mL (9).
  • Electrocardiogram (ECG/EKG)Electrocardiogram (ECG/EKG): L-tetrahydropalmatine (rotundium), an alkaloid of Corydalis turtschaninovii, demonstrated positive antiarrhythmic effects in blocking calcium channels that were similar to other anti-arrhythmics, including bepridil (6).
  • HIV viral loadHIV viral load: Certain alkaloids isolated from Corydalis yanhusuo were shown to inhibit HIV-1 reverse transcriptase (14).