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Cyperus rotundus
Purple nutsedge/Drug Interactions:
Antibiotics
Antibiotics: Based on in vitro studies, induction of apoptosis may provide purple nutsedge with antibacterial properties (
1
;
2
).
Anticoagulants and antiplatelets
Anticoagulants and antiplatelets: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (
3
;
4
;
5
).
Antidiabetic agents
Antidiabetic agents: In lab and animal studies, Cyperus rotundus was found to inhibit protein glycation and reduce blood glucose (
9
;
6
).
Antidiarrheals
Antidiarrheals: In animal studies, the methanol extract of Cyperus rotundus significantly reduced castor oil-induced diarrhea (
10
).
Anti-inflammatory agents
Anti-inflammatory agents: In in vitro studies, an overproduction of nitric oxide and superoxide in the murine macrophage cell line RAW264.7 was inhibited by the methanolic extract of Cyperus rotundus (
12
).
Antimalarial agents
Antimalarial agents: In in vitro research, constituents of Cyperus rotundus showed antimalarial activity (
14
).
Antineoplastic agents
Antineoplastic agents: Based on in vitro studies, Cyperus rotundus may induce programmed cell death (
1
;
2
;
13
).
Cholinesterase inhibitors
Cholinesterase inhibitors: In animal and plant studies, purple nutsedge inhibited acetylcholinesterase (AChE) (
16
).
Drugs that affect GABA
Drugs that affect GABA: Cyperus rotundus is anecdotally said to improve epilepsy. In animal research, one constituent of purple nutsedge, isocurcumenol, interacted in vitro with the benzodiazepine receptor (
17
).
Purple nutsedge/Herb/Supplement Interactions:
Anticoagulants and antiplatelets
Anticoagulants and antiplatelets: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (
3
;
4
;
5
).
Antidiarrheals
Antidiarrheals: In animal studies, the methanol extract of Cyperus rotundus significantly reduced castor oil-induced diarrhea (
10
).
Anti-inflammatory herbs
Anti-inflammatory herbs: In in vitro studies, an overproduction of nitric oxide and superoxide in the murine macrophage cell line RAW264.7 was inhibited by the methanolic extract of Cyperus rotundus (
12
).
Antimalarial herbs and supplements
Antimalarial herbs and supplements: In in vitro research, constituents of Cyperus rotundus showed antimalarial activity (
14
).
Antineoplastics
Antineoplastics: Based on in vitro studies, Cyperus rotundus may induce programmed cell death (
1
;
2
;
13
).
Antioxidants
Antioxidants: Based on in vitro research, Cyperusrotundus may have antioxidant effects (
9
;
1
;
2
;
6
;
7
).
Cholinergic herbs
Cholinergic herbs: In animal and plant studies, purple nutsedge inhibits acetylcholinesterase (AChE) (
16
).
Hypoglycemics
Hypoglycemics: In lab and animal studies, Cyperus rotundus was found to inhibit protein glycation and reduce blood glucose (
9
;
6
).
Purple nutsedge/Food Interactions:
Insufficient evidence.
Purple nutsedge/Lab Interactions:
Blood glucose
Blood glucose: Based on animal studies, Cyperus rotundus may lower blood sugar levels (
9
;
6
).
Coagulation panel
Coagulation panel: In animal studies, a combination of Cyperus rotundus with other herbs (peony root, Cnidium rhizome, safflower, Saussurea root (JP XIV)) inhibited the aggregation of platelets without affecting the prothrombin time (
3
;
4
;
5
).