D-ribose

Ribose/Drug Interactions:

  • Antidiabetic agentsAntidiabetic agents: Based on secondary sources, adverse reactions to ribose may include symptoms of hypoglycemia.
  • Cardiovascular agentsCardiovascular agents: D-ribose (5g/dose, three times daily) in 16 NYHA class III-IV heart failure patients significantly improved ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement (19). D-ribose has been shown in animal models to improve cardiac energy metabolism and function following ischemia (20).
  • Drugs that may lower seizure threshold Drugs that may lower seizure threshold: D-ribose supplementation in a patient with an inherited deficit of adenylosuccinase, severe psychomotor retardation, and epilepsy reduced seizure frequency (18). However, although seizures increased upon attempts to stop ribose supplementation, substitution of D-ribose with D-glucose did not increase seizure activity (18).

    • Ribose/Herb/Supplement Interactions:

  • Antidiabetic agentsAntidiabetic agents: Based on secondary sources, adverse reactions to ribose may include symptoms of hypoglycemia.
  • Cardiovascular herbs and supplementsCardiovascular herbs and supplements: D-ribose (5g/dose, three times daily) in 16 NYHA class III-IV heart failure patients significantly improved ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement (19). D-ribose has been shown in animal models to improve cardiac energy metabolism and function following ischemia (20).
  • Herbs/supplements that lower seizure thresholdHerbs/supplements that lower seizure threshold: D-ribose supplementation in a patient with an inherited deficit of adenylosuccinase, severe psychomotor retardation, and epilepsy reduced seizure frequency (18). However, although seizures increased upon attempts to stop ribose supplementation, substitution of D-ribose with D-glucose did not increase seizure activity (18).

    • Ribose/Food Interactions:

  • Insufficient available evidence.

    • Ribose/Lab Interactions:

  • GlucoseGlucose: Based on secondary sources, adverse reactions to ribose may include symptoms of hypoglycemia.
  • HypoxanthineHypoxanthine: Physiological effects of ribose have included increased plasma hypoxanthine levels 72 hours after cycle training (11).
  • Metabolic markersMetabolic markers: In human evidence, D-ribose supplementation did not have any effects on metabolic markers after high-intensity exercise (21; 8).
  • Thallium stress testThallium stress test: Administration of ribose may increase the detection of viable myocardium during the thallium stress test, particularly in patients with severe left ventricular dysfunction (22; 23; 24).
  • Uric acidUric acid: According to secondary sources, hyperuricemia or hyperuricosuria may occur during ribose supplementation.