Datura stramonium

Jimson weed/Drug Interactions:

  • AlcoholAlcohol: Based on human toxicology reports, Datura stramonium may have additive effects with alcohol (17; 55).
  • AlkaloidsAlkaloids: Based on in vitro and laboratory study, the alkaloids, atropine, hyoscamine and scopolamine, have been identified in jimson weed (29; 51; 43; 11), and, therefore, may have additive effects with concomitant administration of other alkaloids.
  • AmantadineAmantadine: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to have additive anticholinergic effects with amantadine.
  • AnalgesicsAnalgesics: Emergency room treatment of patients with anesthesia who are also under the influence of jimson weed is considered dangerous, due to the respiratory depression induced by anesthesia, which may be additive with that of jimson weed. Anecdotal reports suggest that respiratory arrest may be a symptom of jimson weed poisoning. Respiratory rate of 19 per minute has been reported with ingestion of jimson weed in case study (54).
  • Antiarrythmic agentsAntiarrythmic agents: Based on toxicology reports, jimson weed may cause tachycardia (50; 44; 16) and life threatening arrhythmias (4; 18; 49; 13).
  • Antiasthmatic agentsAntiasthmatic agents: In a case series, inhaling the smoke of one Datura stramonium cigarette decreased specific airway resistance (sRaw) in 11 out of 12 asthmatic patients with mild airway obstruction (25).
  • AnticholinergicsAnticholinergics: According to toxicology reports, jimson weed may cause a potentially lethal atropine-like, anticholinergic syndrome due to the presence of the alkaloids atropine, hyoscamine, and scopolamine (5; 39; 40; 16; 13; 10; 41; 42; 19; 23).
  • Anticholinergics, ophthalmicAnticholinergics, ophthalmic: According to toxicology reports, jimson weed may cause blurred vision (4), cornpicker's pupil (jimson weed mydriasis) (57), and dilated pupils (mydriasis) (4; 50).
  • Anticoagulant agentsAnticoagulant agents: Prolonged prothrombin times have been reported in patients with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion (52).
  • AntidepressantsAntidepressants: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to have additive anticholinergic effects with tricyclic antidepressants.
  • Antihypertensive agentsAntihypertensive agents: Based on toxicology reports, jimson weed may cause hypertension (16), severe hypertension (4), and tachycardia (50; 44). Blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).
  • Antimicrobial agentsAntimicrobial agents: Methanol extracts of the aerial parts of Datura inoxia and Datura stramonium have demonstrated dose dependent antibacterial activity against gram positive bacteria in vitro (26).
  • Antipsychotic agentsAntipsychotic agents: Based on toxicology reports, jimson weed may cause psychiatric effects such as acute psychosis (53), delirium (13), disorientation (49; 13; 31), and hallucinations (38; 4; 49; 16).
  • Anti-seizure agentsAnti-seizure agents: Based on case reports, jimson weed may cause seizures (9; 4; 16).
  • Antitumor agentsAntitumor agents: Based on in vitro study, Datura stramonium agglutinin has been shown to induce irreversible differentiation in C6 glioma cells and in four human glial tumor cells (29).
  • AtropineAtropine: Urinary atropine or scopolamine was detected in 17 out of 26 adolescent patients hospitalized for intentional jimson weed ingestion (44).
  • Beta-blockersBeta-blockers: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to increase the effects of atenolol and digoxin.
  • Cardiac glycosidesCardiac glycosides: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to increase the effects of digoxin, a cardiac glycoside.
  • DigoxinDigoxin: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to increase the effects of digoxin.
  • DiureticsDiuretics: Based on case reports, jimson weed may cause difficulty urinating (4) or urinary retention (16; 44).
  • Heart rate regulating agentsHeart rate regulating agents: Based on toxicology reports, jimson weed may cause sinus tachycardia (16), life threatening arrhythmias (4; 18; 49; 13), and hypertension (16). Blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).
  • Hepatotoxic agentsHepatotoxic agents: Based on human case study, Datura stramonium poisoning may cause fulminant hepatitis (78).
  • ImmunostimulantsImmunostimulants: Granulocytosis as a result of poisoning by Datura stramonium has been reported in case study (87).
  • ImmunosuppressantsImmunosuppressants: Granulocytosis as a result of poisoning by Datura stramonium has been reported in case study (87).
  • Muscarinic antagonistsMuscarinic antagonists: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11), therefore, jimson weed may have additive effects with muscarinic antagonists.
  • Narcotic agentsNarcotic agents: Based on case study, jimson weed may have narcotic effects (56).
  • ScopolamineScopolamine: Urinary atropine or scopolamine was detected in 17 out of 26 adolescent patients hospitalized for intentional jimson weed ingestion (44).
  • SedativesSedatives: Based on case study, jimson weed may have narcotic effects (56).
  • StimulantsStimulants: In case study, blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).

    • Jimson weed/Herb/Supplement Interactions:

  • AlkaloidsAlkaloids: Based on in vitro and laboratory study, the alkaloids, atropine, hyoscamine, and scopolamine, have been identified in jimson weed (29; 51; 43; 11), and, therefore, may have additive effects with concomitant administration of other alkaloids.
  • AnalgesicsAnalgesics: Emergency room treatment of patients with anesthesia who are also under the influence of jimson weed is considered dangerous, due to the respiratory depression induced by anesthesia, which may be additive with that of jimson weed. Anecdotal reports suggested that respiratory arrest may be a symptom of jimson weed poisoning. Respiratory rate of 19 per minute has been reported with ingestion of jimson weed in case study (54).
  • Antiarrythmic herbs and supplementsAntiarrythmic herbs and supplements: Based on toxicology reports, jimson weed may cause tachycardia (50; 44; 16) and life threatening arrhythmias (4; 18; 49; 13).
  • Antiasthmatic herbs and supplementsAntiasthmatic herbs and supplements: In a case series, inhaling the smoke of one Datura stramonium cigarette decreased specific airway resistance (sRaw) in 11 out of 12 asthmatic patients with mild airway obstruction (25).
  • AnticholinergicsAnticholinergics: According to toxicology reports, jimson weed may cause a potentially lethal atropine-like, anticholinergic syndrome due to the presence of the alkaloids atropine, hyoscamine, and scopolamine (5; 39; 40; 16; 13; 10; 41; 42; 19; 23).
  • Anticholinergics, ophthalmicAnticholinergics, ophthalmic: According to toxicology reports, jimson weed may cause blurred vision (4), cornpicker's pupil (jimson weed mydriasis) (57), and dilated pupils (mydriasis) (4; 50).
  • AnticoagulantsAnticoagulants: Prolonged prothrombin times have been reported in patients with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion (52).
  • AntidepressantsAntidepressants: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to have additive anticholinergic effects with tricyclic antidepressants.
  • AntimicrobialsAntimicrobials: Methanol extracts of the aerial parts of Datura inoxia and Datura stramonium have demonstrated dose dependent antibacterial activity against gram positive bacteria in vitro (26).
  • AntipsychoticsAntipsychotics: Based on toxicology reports, jimson weed may cause psychiatric effects such as acute psychosis (53), delirium (13), disorientation (49; 13; 31), and hallucinations (38; 4; 49; 16).
  • Anti-seizure herbs and supplementsAnti-seizure herbs and supplements: Based on case reports, jimson weed may cause seizures (9; 4; 16).
  • Antitumor herbs and supplementsAntitumor herbs and supplements: Based on in vitro study, Datura stramonium agglutinin has been shown to induce irreversible differentiation in C6 glioma cells and in four human glial tumor cells (29).
  • AtropineAtropine: Urinary atropine or scopolamine was detected in 17 out of 26 adolescent patients hospitalized for intentional jimson weed ingestion (44).
  • Cardiac glycosidesCardiac glycosides: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to increase the effects of digoxin, a cardiac glycoside.
  • DiureticsDiuretics: Based on case reports, jimson weed may cause difficulty urinating (4) or urinary retention (16; 44).
  • Foxglove (Digitalis purpurea)Foxglove (Digitalis purpurea): Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11). Based on secondary reports, these agents have been known to increase the effects of digoxin, a constituent found in foxglove.
  • Heart rate regulating supplementsHeart rate regulating supplements: Based on toxicology reports, jimson weed may cause sinus tachycardia (16), life threatening arrhythmias (4; 18; 49; 13), and hypertension (16). Blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).
  • Hepatotoxic herbs and supplementsHepatotoxic herbs and supplements: Based on human case study, Datura stramonium poisoning may cause fulminant hepatitis (78).
  • HypotensivesHypotensives: Based on toxicology reports, jimson weed may cause hypertension (16), severe hypertension (4), and tachycardia (50; 44). Blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).
  • ImmunostimulantsImmunostimulants: Granulocytosis as a result of poisoning by Datura stramonium has been reported in case study (87).
  • ImmunosuppressantsImmunosuppressants: Granulocytosis as a result of poisoning by Datura stramonium has been reported in case study (87).
  • IronIron: Based on laboratory study, lectins from Datura stramonium may interfere with binding of iron in humans (101).
  • Muscarinic antagonistsMuscarinic antagonists: Based on in vitro and laboratory study, the alkaloids atropine and scopolamine have been identified in jimson weed (29; 51; 43; 11), therefore, jimson weed may have additive effects with muscarinic antagonists.
  • ScopolamineScopolamine: Urinary atropine or scopolamine was detected in 17 out of 26 adolescent patients hospitalized for intentional jimson weed ingestion (44).
  • SedativesSedatives: Based on case study, jimson weed may have narcotic effects (56).
  • StimulantsStimulants: In case study, blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).

    • Jimson weed/Food Interactions:

  • Alcoholic beveragesAlcoholic beverages: Based on human toxicology reports, Datura stramonium may have additive effects with alcohol (17; 55).
  • Contaminated foodsContaminated foods: Accidental poisoning from food contaminated with Datura stramonium, such as chapatti and millet, has been reported (12; 102; 103; 18).
  • HoneyHoney: In case study, intoxication with Datura stramonium and Daturainoxia alkaloids following honey ingestion has been reported (104).

    • Jimson weed/Lab Interactions:

  • Blood pressureBlood pressure: Blood pressure of 138/88 and pulse rate of 108 per minute has been reported in a patient who consumed boiled jimson weed (54).
  • Electroencephalogram (EEG)Electroencephalogram (EEG): In case study, abnormal electroencephalograms in 10 patients admitted to the hospital with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion has been reported (52). Slow wave activity and reportedly "bizarre" rhythmical bursts of high-voltage sharp wave activity (that resolved rapidly during the subsequent 24 hours) appeared on EEG's recorded immediately after admission.
  • Heart rateHeart rate: In case reports, sinus tachycardia (16), life threatening arrhythmias (4; 18; 49; 13), and hypertension (16) have been reported with jimson weed ingestion.
  • Lactic dehydrogenaseLactic dehydrogenase: In case reports, elevation of lactic dehydrogenase has been reported in patients with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion (52).
  • Prothrombin timeProthrombin time: Prolonged prothrombin times have been reported in patients with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion (52).
  • Seizure thresholdSeizure threshold: Based on case reports, jimson weed may cause seizures (9; 4; 16).
  • Serum glutamic-oxalacetic transaminaseSerum glutamic-oxalacetic transaminase: Elevation of serum glutamic-oxalacetic transaminase been reported in patients with acute anticholinergic syndrome secondary to jimson weed (Datura stramonium) ingestion (52).
  • Serum ironSerum iron: Based on laboratory study, lectins from Datura stramonium may interfere with binding of iron in humans (101).
  • Serum pancreatic polypeptideSerum pancreatic polypeptide: The use of Datura stramonium suppositories in 16 chronic bronchitis and 24 bronchial asthma patients resulted in a decrease in serum pancreatic polypeptide compared with matched controls (24).
  • WBC countWBC count: Granulocytosis as a result of poisoning by Datura stramonium has been reported (87).