Dexpanthenol

Pantothenic acid/Drug Interactions:

  • Alzheimer's agentsAlzheimer's agents: In theory, pantothenic acid and dexpanthenol may increase the effects of cholinesterase inhibitor drugs (including multiple Alzheimer's drugs) by increasing production of acetylcholine, leading to potentially dangerous side effects.
  • AntiarthriticsAntiarthritics: The effect of calcium pantothenic acid alone or in combination with cysteine hydrochloride on arthritis conditions has been investigated in human research (23; 33).
  • AntibioticsAntibiotics: According to secondary sources, pantothenic acid may have interactions when combined with antibiotics.
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: According to secondary sources, dexpanthenol may increase bleeding time and therefore potentially increase the risk of bleeding when combined with other agents with similar properties, but there is limited evidence in this area, and this is generally not regarded as a serious potential risk.
  • AntihypertensivesAntihypertensives: According to secondary sources, there is some evidence of benefit with respect to heart rate, respiration rate, and blood pressure in individuals.
  • Athletic performance enhancersAthletic performance enhancers: Combination products containing pantothenic acid had mixed results on athletic performance in human research, including improved performance, increased beta-endorphin levels (lacking statistical significance), and reduced fatigue; however, the effects of pantothenic acid alone are unclear (34; 35).
  • Cardiovascular agentsCardiovascular agents: According to secondary sources, there is some evidence of benefit with respect to heart rate, respiration rate, and blood pressure in individuals.
  • Cholinesterase inhibitorsCholinesterase inhibitors: In theory, pantothenic acid and dexpanthenol may increase the effects of cholinesterase inhibitor drugs (including multiple Alzheimer's drugs) by increasing production of acetylcholine, leading to potentially dangerous side effects.
  • Dermatologic agentsDermatologic agents: In human research, benefits of dexpanthenol in creams and ointments were mixed (20; 21; 36; 15; 37; 29; 22).
  • Eye dropsEye drops: In human research, dexpanthenol-containing eye drops offered benefit for corneal epithelial permeability and congestion of the conjunctiva (17; 19; 27).
  • Gastrointestinal agentsGastrointestinal agents: In patients treated with an enema containing dexpanthenol, abdominal cramping was reported by all participants, and one participant experienced ulcerative colitis disease progression (13). Some participants receiving 400mg of oral panthenol daily or 1,000mg of intramuscular panthenol daily for five days experienced colic and diarrhea. However, the authors reported that these side effects represented signs of effectiveness, rather than an adverse effect (24).
  • Hormonal agentsHormonal agents: According to secondary sources, drugs containing estrogen and progestin may increase the daily requirement of pantothenic acid.
  • LaxativesLaxatives: The effect of Bepanthene? (dexpanthenol) on constipation has been investigated, and benefits were indicated in terms of the number of subjects having a bowel movement within one day (24).
  • Oral contraceptivesOral contraceptives: According to secondary sources, drugs containing estrogen and progestin may increase the daily requirement of pantothenic acid.
  • RisperidoneRisperidone: In children, intake of risperidone had a lack of effect on nutritional balance, including pantothenic acid (38).
  • VitaminsVitamins: According to a dietary intake survey, low intakes of calcium, folate, nicotinic acid, vitamin E, retinol, and beta-carotene, and high intakes of pantothenic acid, biotin, and riboflavin are associated with increased genome instability (31). The clinical significance is unclear.

    • Pantothenic acid/Herb/Supplement Interactions:

  • Alzheimer's agentsAlzheimer's agents: In theory, pantothenic acid and dexpanthenol may increase the effects of cholinesterase inhibitor drugs (including multiple Alzheimer's drugs) by increasing production of acetylcholine, leading to potentially dangerous side effects.
  • AntiarthriticsAntiarthritics: The effect of calcium pantothenic acid alone or in combination with cysteine hydrochloride on arthritis conditions has been investigated in human research (23; 33).
  • AntibioticsAntibiotics: According to secondary sources, pantothenic acid may have interactions when combined with antibiotics.
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: According to secondary sources, dexpanthenol may increase bleeding time and therefore potentially increase the risk of bleeding when combined with other agents with similar properties, but there is limited evidence in this area, and this is generally not regarded as a serious potential risk.
  • AntihypertensivesAntihypertensives: According to secondary sources, there is some evidence of benefit with respect to heart rate, respiration rate, and blood pressure in individuals.
  • Athletic performance enhancersAthletic performance enhancers: Combination products containing pantothenic acid had mixed results on athletic performance in human research, including improved performance, increased beta-endorphin levels (lacking statistical significance), and reduced fatigue; however, the effects of pantothenic acid alone are unclear (34; 35).
  • BiotinBiotin: According to secondary sources, high doses of pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine.
  • Cardiovascular agentsCardiovascular agents: According to secondary sources, there is some evidence of benefit with respect to heart rate, respiration rate, and blood pressure in individuals.
  • Cholinesterase inhibitorsCholinesterase inhibitors: In theory, pantothenic acid and dexpanthenol may increase the effects of cholinesterase inhibitor drugs (including multiple Alzheimer's drugs) by increasing production of acetylcholine, leading to potentially dangerous side effects.
  • Dermatological agentsDermatological agents: In human research, benefits of dexpanthenol in creams and ointments are mixed (20; 21; 36; 15; 37; 29; 22).
  • Eye dropsEye drops: In human research, dexpanthenol-containing eye drops offered benefit for corneal epithelial permeability and congestion of the conjunctiva (17; 19; 27).
  • Gastrointestinal agentsGastrointestinal agents: In patients treated with an enema containing dexpanthenol, abdominal cramping was reported by all participants, and one participant experienced ulcerative colitis disease progression (13). Some participants receiving 400mg of oral panthenol daily or 1,000mg of intramuscular panthenol daily for five days experienced colic and diarrhea. However, the authors reported that these side effects represented signs of effectiveness, rather than an adverse effect (24).
  • Hormonal agentsHormonal agents: According to secondary sources, drugs containing estrogen and progestin may increase the daily requirement of pantothenic acid.
  • LaxativesLaxatives: The effect of Bepanthene? (dexpanthenol) on constipation has been investigated, and benefits were indicated in terms of the number of subjects having a bowel movement within one day (24).
  • Oral contraceptivesOral contraceptives: According to secondary sources, drugs containing estrogen and progestin may increase the daily requirement of pantothenic acid.
  • Vitamin CVitamin C: The effect of a sustained-release vs. a regular multivitamin supplement upon vitamin C status was investigated (39). Further details are lacking.

    • Pantothenic acid/Food Interactions:

  • Semipurified dietSemipurified diet: In human research, consumption of a semipurified diet for seven days resulted in changes in blood and urine levels of vitamins, including pantothenic acid (40). Further details are lacking.

    • Pantothenic acid/Lab Interactions:

  • Blood pressureBlood pressure: According to secondary sources, there is some evidence of benefit with respect to heart rate, respiration rate, and blood pressure in individuals.
  • CarnitineCarnitine: In human research, effects of pantothenic acid were lacking on serum and urine carnitine (41).
  • Coagulation panelCoagulation panel: According to secondary sources, dexpanthenol may increase bleeding time and therefore potentially increase the risk of bleeding when combined with other agents with similar properties, but there is limited evidence in this area, and this is generally not regarded as a serious potential risk.
  • Lipid profileLipid profile: In human research, effects of pantothenic acid were lacking on lipid profile and lipid fractions (41).
  • Intestinal bacteriaIntestinal bacteria: In human research, use of a fructooligo- and fructopolysaccharide product, containing vitamins such as pantothenic acid, corrected the intestinal microbiota (42). The effect of pantothenic acid is not clear.