Durian

Durian/Drug Interactions:

  • AlcoholAlcohol: According to secondary sources, durian is harmful when eaten simultaneously along with alcohol consumption. A clinical case showed that an Indian woman died after eating durian and drinking alcohol (7). The combination of alcohol and durian may also cause flatulence and fullness of the abdomen (9). Durian has also been shown to inhibit the absorption of alcohol (10).
  • AntibioticsAntibiotics: According to secondary sources, mustard oils, constituents of durian, have bacterial action. The antibacterial action, however, is not supported by case reports or clinical trials.
  • AntidiabeticsAntidiabetics: In diabetic patients, after ingestion of mango, glucose and insulin areas under the curve were both lower compared to the effect of durian (6).
  • AntihypertensivesAntihypertensives: Based on anecdotal evidence, durian may cause hypertension. Theoretically, durian may interfere with antihypertensive therapy.
  • AntilipemicsAntilipemics: In an animal study, diets supplemented with durian hindered the rise in plasma lipids (2; 3). According to animal study, mon thong durian, when compared to chani and kan yao durians, is preferable for the supplementation of the diet, as it positively influenced the lipid, antioxidant, protein, and metabolic status (11). Theoretically, concurrent use of durian with antilipemic agents may have additive effects.

    • Durian/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: According to secondary sources, mustard oils, constituents of durian, have bacterial action. The antibacterial action, however, is not supported by case reports or clinical trials.
  • AntilipemicsAntilipemics: In an animal study, diets supplemented with durian hindered the rise in plasma lipids (2; 3). According to animal study, mon thong durian, when compared to chani and kan yao durians, is preferable for the supplementation of the diet, as it positively influenced the lipid, antioxidant, protein, and metabolic status (11). Theoretically, concurrent use of durian with antilipemic agents may have additive effects.
  • AntioxidantsAntioxidants: In vitro studies show that Durio species have antioxidant activity (1; 2). Among five Durio species (mon thong, chani, kan yao, pung manee, and kradum), mon thong, chani, and pung manee had higher antioxidant bioactivity (1). In Wistar rats fed cholesterol diets supplemented with durian hindered the decrease in antioxidant activity (2; 3). Theoretically, concurrent use of durian and antioxidant agents may have additive effects.
  • Betel leavesBetel leaves: According to a secondary source, betel leaves ease digestion when eaten after durian.
  • HypoglycemicsHypoglycemics: In diabetic patients, after ingestion of mango, glucose and insulin areas under the curve were both lower compared to the effect of durian (6).
  • HypotensivesHypotensives: Based on anecdotal evidence, durian may cause hypertension. Theoretically, durian may interfere with antihypertensive therapy.

    • Durian/Food Interactions:

  • Insufficient available evidence.

    • Durian/Lab Interactions:

  • InsulinInsulin: In diabetic patients, after ingestion of mango, glucose and insulin areas under the curve were both lower compared to the effect of durian (6).
  • Lipid profileLipid profile: In rats ingesting a high cholesterol diet, durian supplementation hindered the rise in plasma lipids (2; 3).