Eurycoma longifolia

Eurycoma longifolia/Drug Interactions:

  • AntiadrenergicAntiadrenergic: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • Antianxiety agentsAntianxiety agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34). In mice, extract fractions of Eurycoma longifolia had anxiolytic effects, resulting in decreased fighting and more exploration in an open field test (measures willingness to explore) (49). The extract increased the number of squares crossed in the test and increased mobility. In the elevated-maze test, the extract increased the number of entries and time spent in open arms and decreased the number of entries and time spent in closed arms (test of anxiety based on rodents' dislike of open arms).
  • AntibioticsAntibiotics: Alcoholic, acetone, and aqueous extracts of Eurycoma longifolia had antibacterial effects against various Gram-negative and Gram-positive bacteria (50; 51).
  • AntidiabeticsAntidiabetics: In animal research, Eurycoma longifolia reduced blood glucose in hyperglycemic animals (33).
  • AntihypertensivesAntihypertensives: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • AntimalarialsAntimalarials: In animal research, parasitemia suppression of Plasmodium yoelii-infected mice was shown (52). Ethanol and methanol-ethanol extracts of roots and constituents of E. longifolia had antiplasmodial effects against Plasmodium falciparum in culture (53; 54; 55; 56; 57). In animal research, a combination of Eurycoma longifolia extract and artemisinin improved parasitemia suppression of Plasmodium yoelii-infected mice vs. artemisinin alone (52).
  • AntineoplasticsAntineoplastics: In vitro, quassinoid constituents and extracts of Eurycoma longifolia were cytotoxic against cancer cell lines (58; 59; 60; 61; 62; 63; 56).
  • Antiobesity agentsAntiobesity agents: In humans, E. longifolia increased fat free mass, reduced body fat, and increased muscle strength and size (41).
  • Beta-blockers (beta-adrenergic antagonists)Beta-blockers (beta-adrenergic antagonists): In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • Cardiovascular agentsCardiovascular agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • Cytochrome P450-modifying agentsCytochrome P450-modifying agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34). Conversely, in vitro, the effects of Eurycoma longifolia were considered negligible by the authors against cytochrome P450 enzymes (64).
  • Drugs used for osteoporosisDrugs used for osteoporosis: In an aged orchidectomized rat model, Eurycoma longifolia had antiosteoporotic (maintaining bone calcium levels) effects (65).
  • Ergogenic agentsErgogenic agents: The ergogenic effects of Eurycoma longifolia were discussed in a review (66).
  • Fertility agentsFertility agents: In humans, sperm motility significantly increased with use of Eurycoma longifolia (42). In animal studies, Eurycoma longifolia increased copulatory behavior in noncopulator, middle-aged, or sexually sluggish and impotent male rats (67; 68; 69; 70; 71; 72); increased episodes of penile reflexes in male rats (73); increased aphrodisiac and sexual motivation enhancement effects in sexually na?ve male mice (74; 75; 76) and rats (77); and decreased sexual hesitation in middle-aged rats (78). In animal research, Eurycoma longifolia fractions increased sexual orientation activities in middle-aged male rats (79) and sexual orientation activities and mounting frequency in sexually experienced male rats (80; 81). In male rats, E. longifolia improved sexual performance (75). Improved sperm parameters (sperm count, motility, and viability) (82; 83; 84) and testosterone (84) have also been shown in animal models.
  • Heart rate-regulating agentsHeart rate-regulating agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • Hormonal agentsHormonal agents: Eurycomanone, a constituent of Eurycoma longifolia, had antiestrogenic effects against the 17alpha-ethynylestradiol (EE)-induced uterotrophy of immature rats (85). In animal research, Eurycoma longifolia increased testosterone levels (84).
  • ImmunosuppressantsImmunosuppressants: According to secondary sources, Eurycoma longifolia should not be used by people taking immunosuppressant drugs.
  • PropranololPropranolol: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • SympatholyticsSympatholytics: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).

    • Eurycoma longifolia/Herb/Supplement Interactions:

  • AntiadrenergicAntiadrenergic: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • AntiarrhythmicsAntiarrhythmics: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • AntibacterialsAntibacterials: Alcoholic, acetone, and aqueous extracts of Eurycoma longifolia had antibacterial effects against various Gram-negative and Gram-positive bacteria (50; 51).
  • AntimalarialsAntimalarials: In animal research, parasitemia suppression of Plasmodium yoelii-infected mice was shown (52). Ethanol and methanol-ethanol extracts of roots and constituents of E. longifolia had antiplasmodial effects against Plasmodium falciparum in culture (53; 54; 55; 56; 57).
  • AntineoplasticsAntineoplastics: In vitro, quassinoid constituents and extracts of Eurycoma longifolia were cytotoxic against cancer cell lines (58; 59; 60; 61; 62; 63; 56).
  • Antiobesity agentsAntiobesity agents: In humans, E. longifolia increased fat free mass, reduced body fat, and increased muscle strength and size (41).
  • Cardiovascular agentsCardiovascular agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • Cytochrome P450-modifying agentsCytochrome P450-modifying agents: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34). Conversely, in vitro, the effects of Eurycoma longifolia were considered negligible by the authors against cytochrome P450 enzymes (64).
  • Ergogenic agentsErgogenic agents: The ergogenic effects of Eurycoma longifolia were discussed in a review (66).
  • Fertility agentsFertility agents: In humans, sperm motility significantly increased with use of Eurycoma longifolia (42). In animal studies, Eurycoma longifolia increased copulatory behavior in noncopulator, middle-aged, or sexually sluggish and impotent male rats (67; 68; 69; 70; 71; 72); increased episodes of penile reflexes in male rats (73); increased aphrodisiac and sexual motivation enhancement effects in sexually na?ve male mice (74; 75; 76) and rats (77); and decreased sexual hesitation in middle-aged rats (78). In animal research, Eurycoma longifolia fractions increased sexual orientation activities in middle-aged male rats (79) and sexual orientation activities and mounting frequency in sexually experienced male rats (80; 81). In male rats, E. longifolia improved sexual performance (75). Improved sperm parameters (sperm count, motility, and viability) (82; 83; 84) and testosterone (84) have also been shown in animal models.
  • Hormonal agentsHormonal agents: Eurycomanone, a constituent of Eurycoma longifolia had antiestrogenic effects against the 17alpha-ethynylestradiol (EE)-induced uterotrophy of immature rats (85). In animal research, Eurycoma longifolia increased testosterone levels (84).
  • Hypertensives/HypotensivesHypertensives/Hypotensives: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34).
  • HypoglycemicsHypoglycemics: In animal research, Eurycoma longifolia reduced blood glucose in hyperglycemic animals (33).
  • ImmunomodulatorsImmunomodulators: According to secondary sources, Eurycoma longifolia should not be used by people taking immunosuppressant drugs.
  • Osteoporosis agentsOsteoporosis agents: In an aged orchidectomized rat model, Eurycoma longifolia had antiosteoporotic (maintaining bone calcium levels) effects (65).
  • SedativesSedatives: In healthy males, a water-based extract of Eurycoma longifolia decreased the bioavailability (by absorption) of propranolol (34). In mice, extract fractions of Eurycoma longifolia had anxiolytic effects (49).

    • Eurycoma longifolia/Food Interactions:

  • Insufficient available evidence.

    • Eurycoma longifolia/Lab Interactions:

  • Blood glucoseBlood glucose: In animal research, Eurycoma longifolia reduced blood glucose in hyperglycemic animals (33). According to secondary sources, Eurycoma longifolia increased glucose levels in humans.
  • Blood lipidsBlood lipids: According to secondary sources, Eurycoma longifolia increased HDL cholesterol levels in humans.
  • Body fatBody fat: In humans, E. longifolia increased fat free mass, reduced body fat, and increased muscle strength and size (41).
  • CortisolCortisol: According to secondary sources, Eurycoma longifolia decreased cortisol levels in humans.
  • HormonesHormones: In animal research, Eurycoma longifolia increased testosterone levels (84; 71). According to secondary sources (unpublished results), Eurycoma longifolia increased testosterone and dehydroepiandrosterone (DHEA) levels in humans.
  • Insulin-like growth factor (IGF-1)Insulin-like growth factor (IGF-1): According to secondary sources, Eurycoma longifolia modulated the release of IGF-1 in humans, decreasing levels in women.
  • Semen parametersSemen parameters: In humans, sperm motility significantly increased with use of Eurycoma longifolia (42). In animal research, Eurycoma longifolia improved sperm parameters (sperm count, motility, and viability) (82; 83; 84).