Fermented wheat germ extract

Fermented Wheat Germ/Drug Interactions:

  • AntidiabeticsAntidiabetics: According to secondary sources, wheat germ products may have high carbohydrate content.
  • AntineoplasticsAntineoplastics: In clinical trial, fermented wheat germ extract (FWGE) administration may improve the survival rate in patients with various malignancies (11; 15; 2). In vitro, FWGE administration reduced activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis (16) and inhibited cell growth (6). Based on review, it is safe to administer FWGE with anticancer drugs (17). In animal study, administration of FWGE did not inhibit the anticancer effect of cytostatic agents (18). In vivo, FWGE affected the absorption of 5-fluorouracil (5-FU) and dacarbazine (DTIC) under experimental conditions (4).
  • Disease-modifying antirheumatic drugs (DMARDs)Disease-modifying antirheumatic drugs (DMARDs): Based on human study, FWGE supplementation with standard therapies (such as DMARDs) for rheumatoid arthritis (RA) is beneficial for patients with RA, potentially reducing the amount of steroids needed (1).
  • ImmunosuppressantsImmunosuppressants: According to animal study, Avemar? increased blastic transformation of peripheral blood T lymphocytes (19). Other animal study demonstrated immunomodulatory effects of Avemar? as well (12; 13; 14).

    • Fermented Wheat Germ/Herb/Supplement Interactions:

  • Antineoplastic herbs and supplementsAntineoplastic herbs and supplements: Based on clinical trial, FWGE administration may improve the survival rate in patients with various malignancies (11; 15; 2). In vitro, FWGE administration reduced the activity of ribonucleotide reductase, the key enzyme of de novo DNA synthesis (16) and inhibited cell growth (6). Based on a review, it is safe to administer FWGE with anticancer drugs (17). In animal study, administration of FWGE did not inhibit the anticancer effect of cytostatic agents (18). In vivo, FWGE may affect the absorption of 5-fluorouracil (5-FU) and dacarbazine (DTIC) under experimental conditions (4)
  • AntioxidantsAntioxidants: Animal study has suggested that Avemar? contains large amounts of chinolonics and flavonoids, which have demonstrated potent antioxidant effects (13).
  • Hyperglycemics/hypoglycemicsHyperglycemics/hypoglycemics: According to secondary sources, wheat germ products may have high carbohydrate content.
  • ImmunomodulatorsImmunomodulators: According to animal study, Avemar? increased blastic transformation of peripheral blood T lymphocytes (19). Other animal study has demonstrated immunomodulatory effects of Avemar? as well (12; 13; 14).
  • Vitamin CVitamin C: According to secondary sources, FWGE should not be taken in conjunction with any preparation containing vitamin C.

    • Fermented Wheat Germ/Food Interactions:

  • Vitamin CVitamin C: According to secondary sources, FWGE should not be taken in conjunction with any preparation containing vitamin C. FWGE is advised to be taken at least two hours before or after consuming vitamin C.

    • Fermented Wheat Germ/Lab Interactions:

  • Complete blood count (CBC)Complete blood count (CBC): According to secondary sources, oral administration of FWGE treatment in humans had no deleterious effect on hematological status (white blood cell count, red blood cell count, hemoglobin level, hematocrit, platelet count, erythrocyte sedimentation rate, lymphocyte count, neutrophils granulocyte count, monocyte count, eosinophil granulocyte count, prothrombin level, prothrombin activity, coagulation potential, thromboplastin time, thrombin time, and fibrinogen production). All the lab values were within normal limits.