Fumaria

Fumaria/Drug Interactions:

  • Acne medicationAcne medication: A lotion containing tinctures of calendula and fumaria was reported to be beneficial for the treatment of juvenile acne (22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28).
  • AntifungalsAntifungals: In an in vitro study, fumaria alkaloid derivative displayed significant antifungal activity at 8mcg/mL concentration (24).
  • Anti-inflammatory agentsAnti-inflammatory agents: In animal models, fumaria was reported to have anti-inflammatory activity (27).
  • AntineoplasticsAntineoplastics: Fumaria has been reported to have antineoplastic effects in human and rat studies (43; 44). In laboratory study, Fumaria parviflora extract has been shown to modulate critical events regulating pro- and anti-apoptotic proteins in mitochondria-dependent apoptosis induced by nimesulide (45).
  • AntiparasiticsAntiparasitics: In animal studies, fumaria has been reported to have antiparasitic activity (25; 26).
  • AntipyreticsAntipyretics: A rabbit study found antipyretic effects by Fumaria parviflora comparable in potency to aspirin (46).
  • AntispasmodicsAntispasmodics: In vitro studies using rodent small intestine noted that the crude whole plant extract of Fumaria indica and its fractions had spasmogenic and spasmolytic effects (29).
  • AntiviralAntiviral: Fumaria might potentiate antiviral and antifungal drugs. An in vitro study reported that fumaria alkaloid derivative did not present any notable antibacterial effect; however, they had significant antifungal activity at 8mcg/mL concentration. Seven derivatives of alkaloids obtained from some Fumaria and Corydalis species growing in Turkey were evaluated for their in vitro antiviral and antimicrobial activities(24).
  • Cardiovascular drugsCardiovascular drugs: Theoretically, based on alkaloid constituents, fumaria may interact with cardioactive drugs.
  • Cholinesterase inhibitorsCholinesterase inhibitors: Fumaria was reported to have anticholinesterase activity in in vitro studies (47).
  • CNS depressantsCNS depressants: Fumaria might potentiate the central nervous system (CNS) depressants. An in vitro and a rat study reported CNS depressant activity from fumaria alkaloids (6; 32).

    • Fumaria/Herb/Supplement Interactions:

  • Acne herbsAcne herbs: A lotion containing tinctures of calendula and fumaria was reported to be beneficial for the treatment of juvenile acne (22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28).
  • AntifungalsAntifungals: In an in vitro study, fumaria alkaloid derivative displayed significant antifungal activity at 8mcg/mL concentration (24).
  • Anti-inflammatory herbsAnti-inflammatory herbs: In animal models, fumaria was reported to have anti-inflammatory activity; therefore, it might increase the effectiveness of anti-inflammatory drugs (27).
  • AntineoplasticsAntineoplastics: Fumaria has been reported to have antineoplastic effects in human and rat studies; therefore, it might augment the effects of anticancer drugs (43; 44).
  • AntiparasiticsAntiparasitics: In animal studies, fumaria has been reported to have antiparasitic activity (25; 26).
  • AntipyreticsAntipyretics: A rabbit study found antipyretic effects by Fumaria parviflora comparable in potency to aspirin (46).
  • AntispasmodicsAntispasmodics: In vitro studies using rodent small intestine noted that the crude whole plant extract of Fumaria indica and its fractions had spasmogenic and spasmolytic effects (29).
  • Cardioactive herbs and supplementsCardioactive herbs and supplements: Theoretically, based on alkaloid constituents, fumaria may interact with cardioactive herbs and supplements.
  • CholinergicsCholinergics: Fumaria was reported to have anticholinesterase activity in in vitro studies (47).
  • SedativesSedatives: Fumaria might potentiate the CNS depressants. An in vitro and a rat study reported CNS depressant activity from fumaria alkaloids (6; 32).

    • Fumaria/Food Interactions:

  • Insufficient available evidence.

    • Fumaria/Lab Interactions:

  • Cholinesterase levelCholinesterase level: An in vitro study reported that fumaria possessed anticholinesterase activity; it displayed highly potent inhibition compared to the standard at a 1mg/mL concentration (47); therefore, fumaria might lower serum cholinesterase levels.
  • Coagulation panelCoagulation panel: Sanguinarine is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis and other poppy-fumaria species. An in vitro study suggested that sanguinarine has the potential to be an effective antiplatelet agent (28); therefore, it might decrease platelet aggregation.
  • Liver function testsLiver function tests: In vitro studies have reported that fumaria lowered liver enzymes such as SGOT and SGPT (34; 35; 36; 37; 38).