Gamma oryzanol

Gamma oryzanol/Drug Interactions:

  • AnticoagulantsAnticoagulants: According to an animal study, oryzanol and a high cholesterol diet (1% cholesterol) may inhibit platelet aggregation induced by ADP and may totally inhibited aggregation induced by collagen; however, a control diet did not seem alter platelet aggregation (23).
  • AntihyperglycemicsAntihyperglycemics: According to an animal study, gamma oryzanol may increase insulin sensitivity in diabetics (26).
  • Central nervous system suppressantsCentral nervous system suppressants: In pharmacological tests, cycloartenol ferulic acid ester, a component of gamma oryzanol, may have a suppressant effect on the central nervous system; its properties seemed different from those of existing major and minor tranquilizers (24).
  • Cholesterol-lowering drugsCholesterol-lowering drugs: In several clinical and animal studies, gamma oryzanol has shown significant hypocholesterolemic effects (4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 29; 30; 31; 32; 33; 33; 26).
  • Growth hormoneGrowth hormone: According to an animal study, a subcutaneous injection of gamma oryzanol may suppress growth hormone synthesis (25).
  • ImmunomodulatorsImmunomodulators: According to an animal study, gamma oryzanol may moderately stimulate the immune system (27).
  • Luteinizing hormone and luteinizing hormone-releasing hormoneLuteinizing hormone and luteinizing hormone-releasing hormone: According to an animal study, gamma oryzanol injection may suppress luteinizing hormone and may also reduce luteinizing hormone release induced by luteinizing hormone-releasing hormone (28).
  • ProlactinProlactin: According to an animal study, a subcutaneous injection of gamma oryzanol may suppress prolactin release (25).
  • Thyroid drugsThyroid drugs: According to a clinical study, gamma oryzanol may reduce thyroid stimulating hormone (TSH) in patients with hypothyroidism (34).

    • Gamma oryzanol/Herb/Supplement Interactions:

  • AnticoagulantsAnticoagulants: According to animal study, oryzanol and a high cholesterol diet (1% cholesterol) may inhibit platelet aggregation induced by ADP and may totally inhibit aggregation induced by collagen; however, a control diet did not seem alter platelet aggregation (23).
  • Central nervous system suppressantsCentral nervous system suppressants: In pharmacological tests, cycloartenol ferulic acid ester, a component of gamma oryzanol, may have a suppressant effect on the central nervous system; its properties seemed different from those of existing major and minor tranquilizers (24).
  • HypoglycemicsHypoglycemics: According to an animal study, gamma oryzanol may increase insulin sensitivity in diabetics (26).
  • ImmunomodulatorsImmunomodulators: According to an animal study, gamma oryzanol may moderately stimulate the immune system (27).
  • Thyroid active agentsThyroid active agents: According to a clinical study, gamma oryzanol may reduce thyroid stimulating hormone (TSH) in patients with hypothyroidism (34).

    • Gamma oryzanol/Food Interactions:

  • Safflower oilSafflower oil: Blending gamma oryzanol with safflower oil at a specific proportion may magnify their hypocholesterolemic efficacy (5; 6; 7).

    • Gamma oryzanol/Lab Interactions:

  • Coagulation panelCoagulation panel: According to animal study, oryzanol and a high cholesterol diet (1% cholesterol) may inhibit platelet aggregation induced by ADP and may totally inhibit aggregation induced by collagen; however, a control diet did not seem alter platelet aggregation (23).
  • Growth hormone levelsGrowth hormone levels: According to an animal study, a subcutaneous injection of gamma oryzanol may suppress growth hormone synthesis (25).
  • Lipid panelLipid panel: Gamma oryzanol may affect total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels (4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 29; 30; 31; 32; 33; 33; 26).
  • Luteinizing hormone and luteinizing hormone-releasing hormone levelsLuteinizing hormone and luteinizing hormone-releasing hormone levels: According to an animal study, gamma oryzanol injection may suppress luteinizing hormone and may also reduce luteinizing hormone release induced by luteinizing hormone-releasing hormone (28).
  • Prolactin levelsProlactin levels: According to an animal study, a subcutaneous injection of gamma oryzanol may suppress prolactin release (25).
  • Serum glucose levelsSerum glucose levels: According to an animal study, gamma oryzanol may increase insulin sensitivity in diabetics (26).
  • Thyroid stimulating hormone (TSH)Thyroid stimulating hormone (TSH): Gamma oryzanol may reduce serum TSH concentrations (34).