Geranium

Geranium/Drug Interactions:

  • Antianxiety agentsAntianxiety agents: Geranium has been used historically to treat anxiety. However, in a human study, aromatherapy with geranium oil was found to be no more effective than placebo as an anxiolytic (25). Although the genus was not provided in this study, it was likely not Geranium.
  • AntibioticsAntibiotics: In in vitro research, Geranium robertianum displayed antibacterial activity against Staphylococcus epidermidis and Escherichia coli F'lac K12 LE140 (8). Geranium strictipes had antibacterial effects against Staphylococcus aureus (9). In vitro, Geranium maculatum showed no effect against Vibrio cholerae 01 (10).
  • AnticholinergicsAnticholinergics: According to in vitro evidence, Geranium sylvaticum may inhibit acetylcholinesterase activity (23). Theoretically, geranium may interfere with the effects of anticholinergic agents if used concurrently.
  • AntidiarrhealsAntidiarrheals: According to animal research, Geranium incanum Burm. extract may have antidiarrheal activity (24).
  • AntifungalsAntifungals: According to in vitro research, Geranium robertianum displayed antifungal activity against Saccharomyces cerevisiae 0425 delta/1 and 0425 52C yeast strains (8).
  • AntineoplasticsAntineoplastics: According to in vitro evidence, geraniin, a constituent of the Geranium genus, may result in apoptosis in melanoma cells (26). According to animal research, Geranium sibiricum extract may reduce tumor number and the weight of liver metastases (27).
  • AntiprotozoalsAntiprotozoals: Geranium constituents were tested against Giardia lamblia and Entamoeba histolytica trophozoites (14).
  • AntiviralsAntivirals: According to animal research, Geranium sanguineum extract may protect mice from mortality from an experimental influenza A/Aichi/2/68 (H3N2) virus infection (28). According to human research, a combination of Geranium robertianum, Calendula officinalis, Arctium lappa, and acyclovir may be more effective than acyclovir alone for herpetic keratitis (16). According to in vitro evidence, geranium may have antiviral effects against influenza virus, herpes simplex virus, and hepatitis B virus (17; 18; 19; 29).
  • Cholinesterase inhibitorsCholinesterase inhibitors: According to in vitro evidence, Geranium sylvaticum may inhibit acetylcholinesterase activity (23).
  • LaxativesLaxatives: According to animal research, Geranium incanum Burm. extract may have antidiarrheal activity (24). Theoretically, geranium may interfere with the effects of antidiarrheal agents if used concurrently.

    • Geranium/Herb/Supplement Interactions:

  • AnticholinergicsAnticholinergics: According to in vitro evidence, Geranium sylvaticum may inhibit acetylcholinesterase activity (23). Theoretically, geranium may interfere with the effects of anticholinergic agents if used concurrently.
  • AntibacterialsAntibacterials: In in vitro research, Geranium robertianum displayed antibacterial activity against Staphylococcus epidermidis and Escherichia coli F'lac K12 LE140 (8). Geranium strictipes had antibacterial effects against Staphylococcus aureus (9). In vitro, Geranium maculatum showed no effect against Vibrio cholerae 01 (10).
  • AntidiarrhealsAntidiarrheals: According to animal research, Geranium incanum Burm. extract may have antidiarrheal activity (24).
  • AntifungalsAntifungals: In in vitro research, Geranium robertianum displayed antifungal activity against Saccharomyces cerevisiae 0425 delta/1 and 0425 52C yeast strains (8).
  • AntineoplasticsAntineoplastics: According to in vitro evidence, geraniin, a constituent of the Geranium genus, may result in apoptosis in melanoma cells (26). Based on animal study, Geranium sibiricum extract may reduce tumor number and the weight of liver metastases (27).
  • AntioxidantsAntioxidants: According to animal and in vitro research, a polyphenol-rich extract of Geranium sanguineum may have antioxidant effects, reducing hydrogen peroxide-mediated effects and lipid peroxidation (11). According to in vitro research, extract of Geranium robertianum and Geranium sibiricum Linn? may have antioxidant effects (12; 13).
  • AntiparasiticsAntiparasitics: Geranium constituents were tested against Giardia lamblia and Entamoeba histolytica trophozoites (14).
  • AntiviralsAntivirals: According to animal research, Geranium sanguineum extract may protect mice from mortality from an experimental influenza A/Aichi/2/68 (H3N2) virus infection (28). According to human research, a combination of Geranium robertianum, Calendula officinalis, Arctium lappa, and acyclovir may be more effective than acyclovir alone for herpetic keratitis (16). According to in vitro evidence, geranium may have antiviral effects against influenza virus, herpes simplex virus, and hepatitis B virus (17; 18; 19; 29).
  • CholinergicsCholinergics: According to in vitro evidence, Geranium sylvaticum may inhibit acetylcholinesterase activity (23).
  • Insect repellantsInsect repellants: According to human research, topical application of geranium oil may act as an insect repellant (21). However, some studies have found no effect (22). Although the genus was not provided in this study, it was likely not Geranium.
  • SedativesSedatives: Geranium has been used historically to treat anxiety. However, in a human study, aromatherapy with geranium oil was found to be no more effective than placebo as an anxiolytic (25). Although the genus was not provided in this study, it was likely not Geranium.

    • Geranium/Food Interactions:

  • Insufficient available evidence.

    • Geranium/Lab Interactions:

  • Insufficient available evidence.