Gynostemma pentaphyllum
Jiaogulan/Drug Interactions:
Anticancer agentsAnticancer agents: Based on in vitro studies, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects, such as decreasing cancer cell viability, arresting the cell cycle, and inducing apoptosis (4; 6; 7; 8). AntilipemicsAntilipemics: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3). Anti-inflammatoriesAnti-inflammatories: Based on an in vitro study, Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor (2). Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1). Hepatotoxic agentsHepatotoxic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4). Antidiabetic agentsAntidiabetic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels and insulin index scores (4). Jiaogulan/Herb/Supplement Interactions:
Anticancer agentsAnticancer agents: Based on in vitro studies, gypenosides extracted from Gynostemma pentaphyllum may have anticancer effects, such as decreasing cancer cell viability, arresting the cell cycle, and inducing apoptosis (9; 6; 7; 8). AntilipemicsAntilipemics: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3). Anti-inflammatoriesAnti-inflammatories: Based on an in vitro study, Gynostemma pentaphyllum may inhibit nuclear factor-kappaB activation, an important inflammatory factor (2). Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1). Hepatotoxic agentsHepatotoxic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4). Hypoglycemic/hyperglycemic agentsHypoglycemic/hyperglycemic agents: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels (4). Jiaogulan/Food Interactions:
Insufficient available evidence.Jiaogulan/Lab Interactions:
Coagulation panelCoagulation panel: Based on an in vitro study Gynostemma pentaphyllum may significantly inhibit the platelet aggregation, accelerate disaggregation, and inhibit thrombosis (p<0.05). However, based on another in vitro study, Gynostemma pentaphyllum Makino may contain a platelet aggregation factor (1). Insulin levelsInsulin levels: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin levels (4). Insulin resistance indexInsulin resistance index: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease insulin resistance index scores (4). Liver enzymesLiver enzymes: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease alanine aminotransferase, alkaline phosphatase, or aspartate aminotransferase levels (4). Lipid panelLipid panel: Based on a clinical study of patients with nonalcoholic fatty liver disease, Gynostemma pentaphyllum may decrease serum triglyceride levels (4). Based on an in vitro study, Gynostemma pentaphyllum may activate liver X receptors, which play an important role in cholesterol homeostasis by serving as regulatory sensors of cholesterol levels in tissues (3).