Hydrazine
Hydrazine/Drug Interactions:
AlcoholAlcohol: Based on a case report from a clinical study, flushing may occur if alcohol is consumed while on hydrazine sulfate therapy (24). AmphetaminesAmphetamines: Hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and amphetamines may increase the risk of hypertensive crisis (25). Anticonvulsant agentsAnticonvulsant agents: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with anticonvulsant agents may increase the risk of seizures and other adverse effects, including hypertensive crisis, circulatory collapse, and coma.AntidepressantsAntidepressants: As hydrazine sulfate is a monoamine oxidase inhibitor (MAOI), concomitant use of hydrazine and antidepressants may increase the risk of hypertensive crisis or serotonin syndrome (25; 25). (16). Concomitant use of bupropion and hydrazline sulfate may increase the risk of hypertension. Antidiabetic agentsAntidiabetic agents: Based on animal and human study, hydrazine sulfate may decrease plasma glucose and cause hypoglycemia (21; 24; 22; 23). Theoretically, concurrent use of hydrazine sulfate and antidiabetic agents may cause additive effects and increase the risk of hypoglycemia. AntihistaminesAntihistamines: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with histamine blockers is not recommended, due to increased risk of prolonged anticholinergic effects.AntihypertensivesAntihypertensives: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and antihypertensive agents may increase the risk of adverse effects like orthostatic hypotension (25). AntineoplasticsAntineoplastics: Based on animal study (rats), hydrazine sulfate may act synergistically with various antineoplastic agents, including bleomycin (11), methotrexate (52), cyclophosphamide (52), and mitomycin C (52). Antipsychotic agentsAntipsychotic agents: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with antipsychotic agents may increase the risk of sedation and anticholinergic effects.CNS depressantsCNS depressants: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and CNS depressants (including benzodiazepines and barbiturates) may increase the risk of adverse effects (25). Based on secondary sources, these drugs may reduce hydrazine sulfate's effectiveness. CyclobenzaprineCyclobenzaprine: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and cyclobenzaprine may increase the risk of serotonin syndrome (25). DextromethorphanDextromethorphan: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and dextromethorphan may increase the risk of serotonin syndrome (25).(25). Hepatotoxic agentsHepatotoxic agents: Based on human and animal study, hydrazine sulfate may increase liver enzymes (23; 21; 33). Theoretically, concurrent use of hydrazine sulfate and hepatotoxic agents may increase the risk of liver damage. LevodopaLevodopa: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use with levodopa may increase the risk of hypertension and other adverse effects (25). MeperidineMeperidine: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and meperidine may increase the risk of adverse effects, including sweating, excitation, rigidity, hypertensive, coma, and circulatory collapse (25). SympathomimeticsSympathomimetics: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and sympathomimetics may result in hypertensive crisis (25). TramadolTramadol: Based on secondary sources, an increased number of deaths were reported with concurrent use of tramadol and MAO inhibitors. Caution is warranted.Hydrazine/Herb/Supplement Interactions:
AnticonvulsantsAnticonvulsants: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with anticonvulsant agents may increase the risk of seizures and other adverse effects, including hypertensive crisis, circulatory collapse, and coma.Antidepressants, monoamine oxidase inhibitorsAntidepressants, monoamine oxidase inhibitors: As hydrazine sulfate is a monoamine oxidase inhibitor, concomitant use of hydrazine and antidepressants may increase the risk of hypertensive crisis (25). Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with SSRIs may increase the risk of serotonin syndrome.AntihistaminesAntihistamines: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with histamine blockers is not recommended, due to increased risk of prolonged anticholinergic effects.ntineoplasticsAntineoplastics: Based on animal study (rats), hydrazine sulfate may act synergistically with various antineoplastic agents, including bleomycin (11), methotrexate (52), cyclophosphamide (52), and mitomycin C (52). AntipsychoticsAntipsychotics: Hydrazine sulfate is a monoamine oxidase inhibitor and, based on secondary sources, concurrent use with antipsychotic agents may increase the risk of sedation and anticholinergic effects.AnxiolyticsAnxiolytics: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and sedatives may increase the risk of adverse effects (25). Hypoglycemic agentsHypoglycemic agents: Based on animal and human study, hydrazine sulfate may decrease plasma glucose and cause hypoglycemia (21; 24; 22; 23). Theoretically, concurrent use of hydrazine sulfate and antidiabetic agents my cause additive effects and increase the risk of hypoglycemia. Hepatotoxic herbsHepatotoxic herbs: Based on human and animal study, hydrazine sulfate may increase liver enzymes (23; 21; 33). Theoretically, concurrent use of hydrazine sulfate and hepatotoxic agents may increase the risk of liver damage. HypotensivesHypotensives: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and beta-blockers may increase the risk of adverse effects like orthostatic hypotension (25). SedativesSedatives: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and sedatives may increase the risk of adverse effects (25). SympathomimeticsSympathomimetics: As hydrazine sulfate is a monoamine oxidase inhibitor, and concomitant use of hydrazine and sympathomimetics may result in hypertensive crisis (25). Hydrazine /Food Interactions:
Tyramine-containing foodsTyramine-containing foods: As hydrazine sulfate is a mild monoamine oxidase inhibitor, and concomitant consumption of foods rich in tyramine (such as certain cheeses) should be avoided, due to increase risk of hypertensive crisis (1). Hydrazine/Lab Interactions:
5-hydroxyindolacetic acid (5-HIAA)5-hydroxyindolacetic acid (5-HIAA): Based on secondary sources, hydrazine sulfate can decrease urine levels of 5-HIAA and test results.BileBile: Hydrazine may increase urine levels of bile and alter test results secondary to hepatotoxicity (37; 53; 54; 55; 50; 56; 37). Blood glucoseBlood glucose: Based on animal and human study, hydrazine sulfate may decrease plasma glucose and cause hypoglycemia (21; 24; 22; 23). Bone sialoproteinBSP) retentionBone sialoprotein (BSP) retention: Secondary to hepatoxicity, serum concentrations of BSP may be increased, due to hydrazine sulfate administrationLiver function testsLiver function tests: Based on human and animal study, hydrazine sulfate may increase plasma alanine, serum alkaline phosphatase, serum bilirubin, serum glutamic oxalo-acetic transaminase (SGOT), and lactate dehydrogenase (LDH) (23; 21; 33). Lupus erythematosus testLupus erythematosus test: Based on secondary sources, hydrazine sulfate can cause a positive blood test result by activating lupus erythematosus cells.LymphocytesLymphocytes: Based on secondary sources, large doses of hydrazine sulfate can decrease blood lymphocyte levels.MetanephrinesMetanephrines: Based on secondary sources, hydrazine sulfate can increase urine levels of metanephrines and test results.Vanillylmandelic acidVanillylmandelic acid: Based on secondary sources, hydrazine sulfate can increase urine levels and test results.