Jojoba

Jojoba/Drug Interactions:

  • Anti-inflammatory agentsAnti-inflammatory agents: Based on in vitro animal study, jojoba liquid wax reduced carrageenin-induced rat paw edema and prostaglandin E2 (PGE2) levels in inflammatory exudates. In a chick embryo chroioallantoic membrane model, jojoba liquid wax caused a reduction in granulation tissue formation. In rats, croton oil induced ear edema was reduced. In this model, there was also a reduction in neutrophil infiltration (decreased myeloperoxidase activity) and histopathological changes. Jojoba liquid wax reduced nitric oxide levels and tumor necrosis factor-alpha release in a lipopolysaccharide-induced inflammation rat air pouch model (3).
  • Appetite suppressantsAppetite suppressants: Simmondsin isolated from jojoba meal reduces food intake in rats (16), and other studies have postulated appetite suppressing effects (9; 10; 11; 12; 13; 14; 15; 17). Consumption of jojoba meal in combination with appetite suppressants may have additive effects.
  • Antilipemic agentsAntilipemic agents: The effects of jojoba oil on blood cholesterol levels have been investigated in an animal model (35).
  • Mosquito repellantsMosquito repellants: A South African commercial oil containing coconut, jojoba and rapeseed oils has shown ability to act as a mosquito repellant for humans (36). Thus, use of jojoba oil in combination with other mosquito repellants may have additive effects.

    • Jojoba/Herb/Supplement Interactions:

  • Anti-inflammatory herbsAnti-inflammatory herbs: Based on in vitro animal study, jojoba liquid wax reduced carrageenin-induced rat paw edema and prostaglandin E2 (PGE2) levels in inflammatory exudates. In a chick embryo chroioallantoic membrane model, jojoba liquid wax caused a reduction in granulation tissue formation. In rats, croton oil induced ear edema was reduced. In this model, there was also a reduction in neutrophil infiltration (decreased myeloperoxidase activity) and histopathological changes. Jojoba liquid wax reduced nitric oxide levels and tumor necrosis factor-alpha release in a lipopolysaccharide-induced inflammation rat air pouch model (3).
  • AntilipemicsAntilipemics: The effects of jojoba oil on blood cholesterol levels have been investigated in an animal model (35).
  • Appetite suppressantsAppetite suppressants: Simmondsin isolated from jojoba meal reduces food intake in rats (16), and other studies have postulated appetite suppressing effects (9; 10; 11; 12; 13; 14; 15; 17). Consumption of jojoba meal in combination with appetite suppressant herbs or supplements may have additive effects.
  • AromatherapyAromatherapy: Jojoba oil is commonly used as a carrier oil in aromatherapy. Combinations with other carrier oils, such as almond and apricot, with the essential oils from lavender, marjoram, eucalyptus, rosemary and peppermint may offer clinical benefits (25).
  • Mosquito repellantsMosquito repellants: A South African commercial oil containing coconut, jojoba and rapeseed oils has shown ability to act as a mosquito repellant (36). Thus, use of jojoba oil in combination with other mosquito repellant herbs may have additive effects.

    • Jojoba/Food Interactions:

  • Insufficient available evidence.

    • Jojoba/Lab Interactions:

  • Cholesterol panelCholesterol panel: The effects of jojoba oil on blood cholesterol levels have been investigated in an animal model (35).
  • Fecal lipidsFecal lipids: In animals fed jojoba oil for four weeks (2.2-9% of diet), there was an increase in fecal lipid and fecal jojoba oil content (32).
  • HormonesHormones: Levels of plasma growth hormone and thyroxine increased, and levels of plasma insulin-like growth factor-I and triiodothyronine decreased, in animals fed diets of 4% jojoba meal (17).
  • White blood cellsWhite blood cells: In animals fed jojoba oil for four weeks (2.2-9% of diet), there was a dose related increase in white blood cell count (32).