Lophophora spp.

Peyote/Drug Interactions:

  • AlcoholAlcohol: Based on ethnopharmacology, the biochemical alkaloids common in the peyote cactus, rather than just the psychoactive substances (mescaline), are purported to be pharmacologically similar to the neuroamine-derived alkaloids found in the brain during alcohol intoxification (7).
  • AntihypertensivesAntihypertensives: Based on animal study, peyote extracts may regulate blood pressure, although the clinical significance of this is unknown (18; 1; 19; 17).
  • ImmunomodulatorsImmunomodulators: Based on in vitro study, peyote methanolic extracts may stimulate lymphocytes and leukocytes (1).
  • PhenothiazinesPhenothiazines: Based on study of pregnant mice, chlorpromazine may affect the disposition of 8- 14 C-mescaline in fetal and maternal brain and liver (24).
  • PsychoactivesPsychoactives: In theory, due to peyote's hallucinogenic effects, combined used with other psychoactives may cause additive effects (13; 3).
  • SedativesSedatives: Based on historical use, peyote may have additive effects when used with soporifics, such as alcohol, due to additive effects (14).

    • Peyote/Herb/Supplement Interactions:

  • AntipsychoticsAntipsychotics: In theory, due to peyote's hallucinogenic effects, combined used with other psychoactive herbs may cause additive effects (13; 3).
  • HypotensivesHypotensives: Based on animal study, peyote extracts may regulate blood pressure, although the clinical significance of this is unknown (18; 1; 19; 17).
  • ImmunomodulatorsImmunomodulators: Based on in vitro study, peyote methanolic extracts may stimulate lymphocytes and leukocytes (1).
  • SedativesSedatives: Based on historical use, peyote may have additive effects when used with soporifics due to additive effects (14).

    • Peyote/Food Interactions:

  • Insufficient available evidence.

    • Peyote/Lab Interactions:

  • Insufficient available evidence.