Majorana hortensis

Marjoram/Drug Interactions:

  • AlcoholAlcohol: Co-administration of ethanol and the extracts of marjoram volatile oil in rats (Origanum majorana L., Lamiaceae) minimized the hazardous effects of ethanol toxicity on male fertility and on liver and brain tissues (49).
  • AntibioticsAntibiotics: Marjoram has been shown to exert antimicrobial effects in vitro (2; 3; 18; 19) against a variety of bacteria including Salmonella enterica and Shigella. Eugenol, a compound extracted from clove oil and marjoram, was shown to be active against Campylobacter jejuni, Listeria monocytogenes, and Salmonella enterica (4; 5; 6), and against one or more of six Bacillus species (Bacillus amyloliquefaciens ATCC 3842, Bacillus brevis FMC 3, Bacillus cereus FMC 19, Bacillus megaterium DSM 32, Bacillus subtilis IMG 22, and B. subtilis var. niger ATCC 10) (7).
  • AnticholinergicsAnticholinergics: Based on in vitro study, essential oils of various herbs, including marjoram, had inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (70). According to in vitro study, ethanol extracts from Origanum majorana L. may inhibit acetylcholine (15).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In in vitro study, a methanol extract of Origanum majorana inhibited platelet adhesion and affected platelet self-aggregation (35).
  • Antidiabetic agentsAntidiabetic agents: In animal study, water extract of marjoram had hypoglycemic effects (56). Based on in vitro study, Origanum majorana may have antidiabetic and glucose homeostatic effects (36).
  • AntifungalsAntifungals: Based on in vitro research, oxygen uptake by the spores of various fungi, including Fusarium and Trichoderma species, increased in the presence of volatile substances extracted from marjoram (71). Volatile substances from marjoram reduced the spore germination of Mucor racemosus.
  • AntilipemicsAntilipemics: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of triglycerides and total cholesterol (56).
  • AntineoplasticsAntineoplastics: Based on in vitro study, marjoram extracts had antiproliferative effects on the human lymphoblastic leukemia cell line Jurkat (26).
  • AntiprotozoalsAntiprotozoals: Origanum majorana essential oil constituents have been shown to have ovicidal and adulticidal effects against insecticide-susceptible and pyrethroid/malathion-resistant human head lice (Pediculus humanus capitis) (72). Cineole, linalool, camphor, and terpineol monoterpenoid constituents were found to have the most activity, and were faster acting than d-phenothrin and pyrethrum.
  • Antiulcer agentsAntiulcer agents: Based on animal study, marjoram extracts had antiulcerogenic activity against stress-, indomethacin-, and necrotizing agent-induced ulcers (73). Basal gastric secretion and acid output were also reduced, and ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryl (NP-SH) content were replenished.
  • Cholinesterase inhibitorsCholinesterase inhibitors: Based on in vitro study, essential oils of various herbs, including marjoram, had inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (70). According to in vitro study, ethanol extracts from Origanum majorana L. may inhibit acetylcholine (15).
  • DiureticsDiuretics: Based on secondary sources, marjoram may have diuretic properties.
  • IndomethacinIndomethacin: Based on animal study, marjoram extracts had antiulcerogenic activity against indomethacin-induced ulcers (73).

    • Marjoram/Herb/Supplement Interactions:

  • AlcoholAlcohol: Co-administration of ethanol and the extracts of marjoram volatile oil in rats (Origanum majorana L., Lamiaceae) minimized the hazardous effects of ethanol toxicity on male fertility and on liver and brain tissues (49).
  • Ambrosia maritimeAmbrosia maritime: Based on animal study, marjoram extract alone, or in combination with extract of Ambrosia maritime, had comparable hypoglycemic effects (56).
  • AntibacterialsAntibacterials: Marjoram has been shown to exert antimicrobial effects in vitro (2; 3; 18; 19) against a variety of bacteria including Salmonella enterica and Shigella. Eugenol, a compound extracted from clove oil and marjoram, was shown to be active against Campylobacter jejuni, Listeria monocytogenes, and Salmonella enterica (4; 5; 6), and against one or more of six Bacillus species (Bacillus amyloliquefaciens ATCC 3842, Bacillus brevis FMC 3, Bacillus cereus FMC 19, Bacillus megaterium DSM 32, Bacillus subtilis IMG 22, and B. subtilis var. niger ATCC 10) (7).
  • Anticholinergic herbsAnticholinergic herbs: Based on in vitro study, essential oils of various herbs, including marjoram, had inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (70). According to in vitro study, ethanol extracts from Origanum majorana L. may inhibit acetylcholine (15).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: In in vitro study, a methanol extract of Origanum majorana inhibited platelet adhesion and affected platelet self-aggregation (35).
  • AntifungalsAntifungals: Based on in vitro research, oxygen uptake by the spores of various fungi, including Fusarium and Trichoderma species, increased in the presence of volatile substances extracted from marjoram (71). Volatile substances from marjoram reduced the spore germination of Mucor racemosus.
  • AntilipemicsAntilipemics: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of triglycerides and total cholesterol (56).
  • AntineoplasticsAntineoplastics: Based on in vitro study, marjoram extracts had antiproliferative effects on the human lymphoblastic leukemia cell line Jurkat (26).
  • AntioxidantsAntioxidants: Based on animal study, marjoram extract reduced malondialdehyde levels (73). In in vitro study, sweet marjoram was shown to retard lipid oxidation (24), and ursolic acid from sweet marjoram reduced Abeta-induced oxidative cell death (74).
  • AntiparasiticsAntiparasitics: Origanum majorana essential oil constituents have been shown to have ovicidal and adulticidal effects against insecticide-susceptible and pyrethroid/malathion-resistant human head lice (Pediculus humanus capitis) (72). Cineole, linalool, camphor, and terpineol monoterpenoid constituents were found to have the most activity, and were faster acting than d-phenothrin and pyrethrum.
  • Antiulcer herbs and supplementsAntiulcer herbs and supplements: Based on animal study, marjoram extracts had antiulcerogenic activity against stress-, indomethacin-, and necrotizing agent-induced ulcers (73). Basal gastric secretion and acid output were also reduced, and ethanol-induced depleted gastric wall mucus and nonprotein sulfhydryl (NP-SH) content were replenished.
  • DiureticsDiuretics: Based on secondary sources, marjoram may have diuretic properties.
  • HypoglycemicsHypoglycemics: In animal study, water extract of marjoram had hypoglycemic effects (56). Based on in vitro study, Origanum majorana may have antidiabetic and glucose homeostatic effects (36).

    • Marjoram/Food Interactions:

  • Insufficient available evidence.

    • Marjoram/Lab Interactions:

  • Blood glucoseBlood glucose: In animal study, water extract of marjoram had hypoglycemic effects (56). Based on in vitro study, Origanum majorana may have antidiabetic and glucose homeostatic effects (36).
  • Coagulation panelCoagulation panel: In in vitro study, a methanol extract of Origanum majorana inhibited platelet adhesion and affected platelet self-aggregation (35).
  • CreatinineCreatinine: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of creatinine (56).
  • ElectrolytesElectrolytes: Based on secondary sources, marjoram may have diuretic properties. Theoretically this may affect electrolyte levels.
  • Lipid profileLipid profile: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of triglycerides and total cholesterol (56).
  • Liver function testsLiver function tests: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of AST and ALT (56).
  • UreaUrea: Based on animal study, in a diabetic rat model, marjoram extract decreased the elevated levels of urea (56).