Muira puama

Muira puama/Drug Interactions:

  • AnalgesicsAnalgesics: Cross-tolerance with opioids may occur due to similar mechanism of action as shown with combination product Catuama? (containing Ptychopetalum olacoides, Paullinia cupana, Zingiber officinalis, and Trichilia catigua) in animal studies (6). Recent in vivo studies in mice have determined significant antinociceptive properties of Ptychopetalum olacoides extract as well as of the combination product Catuama?, which also showed pronounced analgesic effects (6).
  • Anticoagulant and anti-platelet drugsAnticoagulant and anti-platelet drugs: Due to coumarin constituents of muira puama, actions of warfarin, other anticoagulant and anti-platelet drugs may be potentiated (7; 8; 9).
  • Antidepressant agentsAntidepressant agents: Due to proposed serotonergic effects of muira puama, actions of antidepressants may be altered (10).
  • Antihypertensive drugsAntihypertensive drugs: Muira puama may have hypertensive potential and CNS stimulation, which may alter blood pressure, cardiac functions and CNS effects on cardiac tissue (11).
  • Monoamine oxidase inhibitors (MAOI)Monoamine oxidase inhibitors (MAOI): The combined use of muira puama with MAOIs may potentiate the potential risk for hypertensive crisis (11).
  • Selective serotonin reuptake inhibitor (SSRI) drugsSelective serotonin reuptake inhibitor (SSRI) drugs: Due to serotonergic effects of muira puama, actions of antidepressants may be altered (10).
  • Steroid hormones (estrogen/testosterone)Steroid hormones (estrogen/testosterone): Due to proposed testosterone-like effects as well as positive or negative estrogenic effects, use of muira puama with testosterone or estrogen may result in additive or diminished effects (11).
  • SympathomimeticsSympathomimetics: Combination use may lead to potentiation of sympathomimetic effects (11).

    • Muira puama/Herb/Supplement Interactions:

  • Analgesic herbs/supplementsAnalgesic herbs/supplements: Cross-tolerance with opioids may occur due to similar mechanism of action as shown with combination product Catuama? in animal studies (6). Recent in vivo studies in mice have determined significant antinociceptive properties of Ptychopetalum olacoides extract as well as of the combination product Catuama? (containing Ptychopetalum olacoides, Paullinia cupana, Zingiber officinalis and Trichilia catigua), which also showed pronounced analgesic effects. The herbs action may be related to an interaction with the naloxone sensitive opioid system (6).
  • Anticoagulants and anti-plateletsAnticoagulants and anti-platelets: Due to coumarin constituents of muira puama, actions of anticoagulants and anti-platelets may be altered (7; 8; 9).
  • Antidepressant herbs/supplementsAntidepressant herbs/supplements: Due to proposed serotonergic effects of muira puama, actions of antidepressant herbs may be altered (10).
  • HypotensivesHypotensives: Muira puama may have hypertensive potential and CNS stimulation, which may alter blood pressure, cardiac functions and CNS effects on cardiac tissue (11).
  • Monoamine oxidase inhibitors (MAOI)Monoamine oxidase inhibitors (MAOI): The combined use of muira puama with MAOIs may potentiate the potential risk for hypertensive crisis(11).
  • Steroid herbsSteroid herbs: Due to prosposed testosterone-like effects of muira puama as well as positive or negative estrogenic effects, use of muira puama with testosterone or estrogen-like herbs may result in additive or diminished effects (11).
  • Stimulant herbs/supplementsStimulant herbs/supplements: Combination of muira puama with stimulant herbs may lead to potentiation of sympathomimetic effects (11).
  • YohimbeYohimbe: Hydroalcoholic extract of muira puama may potentiate yohimbine-induced toxicity (10).

    • Muira puama/Food Interactions:

  • Insufficient available evidence.

    • Muira puama/Lab Interactions:

  • International normalized ratio (INR)International normalized ratio (INR): Due to coumarin constituents of muira puama, INR may be altered (7; 8; 9).
  • Prothrombin time (PT)Prothrombin time (PT): Due to coumarin constituents of muira puama, PT may be altered (7; 8; 9).