Perilla

Perilla/Drug Interactions:

  • BarbituatesBarbituates: Theoretically, perilla frutescens may prolong hexobarbital-induced sleep, due to the isolation of dillapiol (13). Isolation of other potentially sedative constituents has been documented (14).
  • Cholesterol-lowering drugsCholesterol-lowering drugs: Theoretically, perilla may lower HDL-cholesterol levels based on animal study.
  • NSAIDSNSAIDS: Theoretically, perilla may suppress indomethacin-induced effects, due to a change in fatty acid and eicosanoid status (15).

    • Perilla/Herb/Supplement Interactions:

  • Beta-caroteneBeta-carotene: Theoretically, the results from an animal study suggest that the combination of perilla and beta-carotene may reduce the risk of colon cancer (16).
  • Cholesterol-lowering herbs and supplementsCholesterol-lowering herbs and supplements: Theoretically, perilla may lower HDL-cholesterol levels based on animal study.
  • Fish oilFish oil: Theoretically, use of fish oil and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
  • Omega-3 fatty acidsOmega-3 fatty acids: Theoretically, use of omega-3 fatty acid sources (flax oil, walnut oil, soybean oil) other than perilla, with perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.

    • Perilla/Food Interactions:

  • FishFish: Theoretically, use of fish and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
  • FlaxFlax: Theoretically, use of flax and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
  • Omega-3 fatty acid-containing foods (general)Omega-3 fatty acid-containing foods (general) : Theoretically, use of omega-3 fatty acid-containing foods and perilla oil would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.
  • WalnutsWalnuts: Theoretically, use of walnuts and perilla would increase omega-3 fatty acid status of blood and tissues to a greater effect than either alone.

    • Perilla/Lab Interactions:

  • FibrinogenFibrinogen: Fibrinogen levels did not change after ten months on a perilla oil enriched diet (17).
  • GlucoseGlucose: Glucose levels did not change after ten months on a perilla oil enriched diet (17).
  • InsulinInsulin: Insulin levels did not change after ten months on a perilla oil enriched diet (17).
  • HbA1cHbA1c: HbA1c levels did not change after ten months on a perilla oil enriched diet (17).
  • LipoproteinsLipoproteins: Total cholesterol and triglycerides did not change after ten months on a perilla oil enriched diet (17). Triglyceride and cholesterol lowering was observed in animal models (18; 19; 20). Based on results in animal studies, perilla oil may result in a decrease in HDL-cholesterol (21).
  • PAI-1PAI-1: PAI-1 concentration did not change after ten months on a perilla oil enriched diet (17).
  • Platelet countPlatelet count: Platelet count or aggregation did not change after ten months on a perilla oil enriched diet (17).
  • Prothrombin timeProthrombin time: Prothrombin time did not change after ten months on a perilla oil enriched diet (17).
  • Serum fatty acidsSerum fatty acids: In elderly subjects, alpha-linolenic acid increased in total serum lipid from 0.8 to 1.6% after three months on a perilla oil enriched diet. Eicosapentaenoic acid and docosahexaenoic acid increased after ten months on a perilla oil enriched diet (2.5 to 3.6% and 5.3 to 6.4%, respectively) (17).
  • Thromboplastin timeThromboplastin time: Thromboplastin time did not change after ten months on a perilla oil enriched diet (17).
  • Tumor necrosis factorTumor necrosis factor: In vitro, a polysaccharide isolated from perilla, as well as perilla juice, has been found to increased tumor necrosis factor production (22; 23). It is not clear if this has clinical relevance.