Perillyl alcohol

Perillyl alcohol/Drug Interactions:

  • AntiemeticsAntiemetics: A combination of antiemetics and perillyl alcohol may have contributed to increased neurological side effects in a clinical trial in advanced cancer patients (7).
  • Cholesterol-lowering agentsCholesterol-lowering agents: According to clinical and in vitro study, perillyl alcohol may decrease in total and HDL-cholesterol or interact with the mevalonate metabolism pathway (12; 14).
  • CisplastinCisplastin: According to an in vitro study, perillyl alcohol may result in a sensitization to cisplastin (15).
  • CompazineCompazine: Premedication use of compazine has been associated with partial amelioration of perillyl alcohol-induced nausea in a phase I trial (7).
  • DoxorubicinDoxorubicin: According to an in vitro study, perillyl alcohol may result in a sensitization to doxorubicin (15).
  • Imatinib mesylate (GleevecT; STI571)Imatinib mesylate (GleevecT; STI571): According to an in vitro study, perillyl alcohol in combination with imatinib mesylate could enhance the proliferation-inhibitory abilities of cells (16).

    • Perillyl alcohol/Herb/Supplement Interactions:

  • AntiemeticsAntiemetics: A combination of antiemetics and perillyl alcohol may have contributed to increased neurological side effects in a clinical trial in advanced cancer patients (7).
  • Cholesterol-lowering agentsCholesterol-lowering agents: According to clinical and in vitro study, perillyl alcohol may decrease in total and HDL-cholesterol or interact with the mevalonate metabolism pathway (12; 14).
  • Perillyl alcohol-containing herbsPerillyl alcohol-containing herbs: Herbs containing perillyl alcohol, including lavender, peppermint, spearmint, celery seeds, sage, lemongrass, ginger grass, savin juniper, Conyza newii, caraway, Perilla frutescens, and wild bergamont, may have additive effects.
  • Red yeast riceRed yeast rice: According to an in vitro study, perillyl alcohol may interact with the mevalonate metabolism pathway (14).

    • Perillyl alcohol/Food Interactions:

  • Ensure?Ensure?: According to a phase I trial, consumption of Ensure? prior to perillyl alcohol dosing had no clear effect on absorption (6). However, a delay was noted in the detection of a metabolite in the serum.
  • Light mealLight meal: According to a phase I trial, ingestion of a light meal before taking perillyl alcohol may partially ameliorate nausea (7).
  • Perillyl alcohol-containing foodsPerillyl alcohol-containing foods: Foods containing perillyl alcohol, including cranberries, cherries may have additive effects.
  • Red yeast riceRed yeast rice: According to an in vitro study, perillyl alcohol may interact with the mevalonate metabolism pathway (14).

    • Perillyl alcohol/Lab Interactions:

  • BilirubinBilirubin: Elevated bilirubin was documented in one breast cancer patient (3).
  • IronIron: Based on a clinical trials of cancer patients, perillyl alcohol may cause anemia (13; 7).
  • LipidsLipids: According to clinical and in vitro study, perillyl alcohol may decrease in total and HDL-cholesterol or interact with the mevalonate metabolism pathway (12; 14).
  • MagnesiumMagnesium: In a clinical trial, hypomagnesemia has been documented (7).
  • PlateletPlatelet: In a clinical trial, thrombocytopenia was noted in one patient (11).
  • PotassiumPotassium: In clinical trials, hypokalemia has been documented (8; 11).
  • White blood cell countWhite blood cell count: Elevated WBC was documented in one breast cancer patient (3). Neutropenia has been documented (11; 7). Leukopenia has been documented (7). Granulocytopenia was noted in two advanced ovarian cancer patients (10).