Phosphatidyl serine

Phosphatidylserine/Drug Interactions:

  • GeneralGeneral: Based on the opinion of an author, phosphatidylserine (PS) is not contraindicated with respect to drugs, is unlikely to interfere with the actions of the few pharmaceuticals available for cognitive decline, and might complement their actions (15).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vitro evidence, PS may have coagulation-promoting activity (20).
  • Anti-inflammatory agentsAnti-inflammatory agents: Based on animal and in vitro evidence, PS may be an endogenous anti-inflammatory molecule, since PS has been shown to be released upon injury and destruction of eukaryotic cells (cells within a complex structure) (18; 19).
  • Athletic performance-enhancing agentsAthletic performance-enhancing agents: Based on human evidence, PS supplementation may weaken the serum cortisol response to acute exercise stress (17). Another study reported that PS might improve golfing performance and perceived stress in golfers (23).
  • Immunomodulating agentsImmunomodulating agents: Based on animal (18) and in vitro research (19), PS may have immunological effects. In animal research, orally administered PS (25mg/kg daily) decreased the production of antigen-specific IgM by splenic lymphocytes (18).
  • Neurologic agentsNeurologic agents: Based on human evidence, a benefit from PS against both age-associated memory impairment (AAMI) and Alzheimer's disease (AD) has been observed (15; 21; 3; 16). Based on animal evidence, a 30-day treatment with ox brain cortex phosphatidylserine (BC-PS) was able to balance the enzymatic functions altered by aging in several brain areas examined (36).

    • Phosphatidylserine/Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vitro evidence, PS may have coagulation-promoting activity (20).
  • Anti-inflammatory agentsAnti-inflammatory agents: Based on animal and in vitro evidence, PS may be an endogenous anti-inflammatory molecule, since it has been shown to be released upon injury and destruction of eukaryotic cells (cells within a complex structure) (18; 19).
  • Athletic performance-enhancing herbs and supplementsAthletic performance-enhancing herbs and supplements: Based on human evidence, PS supplementation may weaken the serum cortisol response to acute exercise stress (17). Another study reported that PS might improve golfing performance and perceived stress in golfers (23).
  • Immunomodulating herbs and supplementsImmunomodulating herbs and supplements: Based on animal (18) and in vitro research (19), PS may have immunological effects. In animal research, orally administered PS (25mg/kg daily) decreased the production of antigen-specific IgM by splenic lymphocytes (18).
  • Neurologic herbs and supplementsNeurologic herbs and supplements: Based on human evidence, a benefit from PS against both age-associated memory impairment (AAMI) and Alzheimer's disease (AD) has been observed (15; 21; 3; 16). Based on animal evidence, a 30-day treatment with ox brain cortex phosphatidylserine (BC-PS) was able to balance the enzymatic functions altered by aging in several brain areas examined (36).

    • Phosphatidylserine/Food Interactions:

  • Insufficient available data.

    • Phosphatidylserine/Lab Interactions:

  • Coagulation panelCoagulation panel: Based on in vitro research, PS may have coagulation-promoting activity (20).
  • CortisolCortisol: Based on human evidence, PS supplementation may weaken the serum cortisol response to acute exercise stress (17).