S. boulardii

Saccharomyces boulardii/Drug Interactions:

  • AntibioticsAntibiotics: Concomitant antibiotic treatment may change gastrointestinal flora, subsequently increasing steady state levels of Saccharomyces boulardii in humans (74). According to various clinical trials, use of Saccharomyces boulardii in combination with antibiotics decreases the frequency and duration of diarrhea (67; 73; 48; 49; 51; 55; 54; 53; 62).
  • Antidiarrheal drugsAntidiarrheal drugs: Based on animal and clinical studies, Saccharomyces boulardii may reduce diarrhea (34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 33; 61; 62; 63; 64; 65; 66).
  • AntifungalsAntifungals: Use may result in decreased efficacy of Saccharomyces boulardii.
  • IodoquinolIodoquinol: Based on a clinical trial, use of metronidazole plus iodoquinol plus Saccharomyces boulardii was more effective than metronidazole plus iodoquinol alone for reducing diarrhea associated with amebiasis (75).
  • MesalamineMesalamine: Based on a clinical trial, use of mesalamine plus Saccharomyces boulardii may be more effective than mesalamine alone for reducing diarrhea associated with Crohn's disease (76).
  • MetronidazoleMetronidazole: Based on a clinical trial, use of metronidazole plus iodoquinol plus Saccharomyces boulardii may be more effective than metronidazole plus iodoquinol alone for reducing diarrhea associated with amebiasis (75).
  • Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs): Saccharomyces boulardii taken in combination with MAOIs may drop blood pressure.

    • Saccharomyces boulardii/Herb/Supplement Interactions:

  • Antibiotic herb or supplementsAntibiotic herb or supplements: Concomitant treatment may change gastrointestinal flora, subsequently increasing steady state levels of Saccharomyces boulardii in humans (74). According to various clinical trials, use of Saccharomyces boulardii in combination with antibiotics decreases the frequency and duration of diarrhea (67; 73; 48; 49; 51; 55; 54; 53; 62).
  • Antidiarrheal herbs and supplementsAntidiarrheal herbs and supplements: Based on animal and clinical studies, Saccharomyces boulardii may reduce diarrhea (34; 35; 36; 37; 38; 39; 40; 41; 42; 43; 44; 45; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 33; 61; 62; 63; 64; 65; 66).
  • Antifungal herbs and supplementsAntifungal herbs and supplements: Combination use may result in decreased efficacy of Saccharomyces boulardii.
  • Monoamine oxidase inhibitors (MAOIs)Monoamine oxidase inhibitors (MAOIs): Saccharomyces boulardii taken in combination with MAOIs may drop blood pressure.

    • Saccharomyces boulardii/Food Interactions:

  • Insufficient data available.

    • Saccharomyces boulardii/Lab Interactions:

  • Blood cell countsBlood cell counts: Based on a clinical trial, Saccharomyces boulardii administration may increase erythrocytes, leukocytes, and neutrophils (77).
  • Complement pathwayComplement pathway: Based on clinical trials, Saccharomyces boulardii administration may increased C3, C5, CH50 and C3d (77), and CD25 expression on CD4 cells in peripheral blood (78).
  • HemoglobinHemoglobin: Based on a clinical trial, Saccharomyces boulardii administration may increase hemoglobin in healthy patients (77).
  • IgAIgA: Based on a rat study, Saccharomyces boulardii administration may increase secretory IgA levels (79).
  • Stool analysisStool analysis: Based on a clinical study in children, Saccharomyces boulardii may be detected and Escherichia coli levels may decrease in stool after treatment (80).