Salacia
Salacia/Drug Interactions:
AntibioticsAntibiotics: In vitro, extracts from the leaves and stems of Salacia beddomei and an extract from the bark of Salacia petenensis exhibited antibacterial activity (10; 11). Antidiabetic agentsAntidiabetic agents: In patients with type 2 diabetes and in healthy humans who took Salacia reticulata tea or Salacia oblonga extract, there was a significant decrease in the postprandial glucose and insulin responses (42; 40; 41; 43). Similar effects were noted in animal and in vitro studies (44; 9; 45; 46; 47; 18; 48; 49; 50; 51; 21; 52; 22; 23; 53; 54; 16; 55). Anti-inflammatory agentsAnti-inflammatory agents: In mice, Salacia reticulata leaf powder exhibited antiarthritic effects (12). In rats, Salacia oblonga root bark powder suppressed the transudative, exudative, and proliferative components of chronic inflammation in a cotton pellet granuloma assay (1). Antilipemic agentsAntilipemic agents: In obese rats, oral administration of Salacia oblonga root extract lowered plasma triglyceride and total cholesterol levels, increased plasma high-density lipoprotein levels, and reduced liver triglycerides, nonesterified fatty acids, and the ratio of fatty droplets to total tissue (30). Antimalarial agentsAntimalarial agents: In vitro, Salacia madagascariensis extracts showed strong antimalarial activity against Plasmodium falciparum (13). Compounds isolated from the roots of Salacia kraussii exhibited antimalarial activity against blood stages of Plasmodium berghei (14). Antineoplastic agentsAntineoplastic agents: Salacia campestris synthesized quinonemethide triterpenoids, thought to have antitumoral properties (15). An extract from Salacia oblonga showed cytotoxicity against Ehrlich ascites tumor cells in vitro (16). A salacinol analog inhibited Drosophila melanogaster Golgi mannosidase II in vitro, indicating a potential for antimetastatic effects (17). Antiobesity agentsAntiobesity agents: In animal research, Salacia oblonga or Salacia reticulata extract caused a reduction in visceral fat mass, body weight, and feed intake (34; 35). Antiparasitic agentsAntiparasitic agents: Constituents isolated from the extract of the roots of Salacia madagascariensis showed potent activity against Leishmania (26). Cardiovascular agentsCardiovascular agents: In diabetic rats, Salacia oblonga root inhibited cardiac fatty acid oxidation and reduced cardiac triglyceride and fatty acid in the myocardium and decreased cardiac hypertrophy and fibrosis (27; 28; 29). Salacia/Herb/Supplement Interactions:
AntibacterialsAntibacterials: In vitro, extracts from the leaves and stems of Salacia beddomei and an extract from the bark of Salacia petenensis exhibited antibacterial activity (10; 11). Anti-inflammatory herbsAnti-inflammatory herbs: In mice, Salacia reticulata leaf powder exhibited antiarthritic effects (12). In rats, Salacia oblonga root bark powder suppressed the transudative, exudative, and proliferative components of chronic inflammation in a cotton pellet granuloma assay (1). AntilipemicsAntilipemics: In obese rats, oral administration of Salacia oblonga root extract lowered plasma triglyceride and total cholesterol levels, increased plasma high-density lipoprotein levels, and reduced liver triglycerides, nonesterified fatty acids, and the ratio of fatty droplets to total tissue (30). Antimalarial herbs and supplementsAntimalarial herbs and supplements: In vitro, Salacia madagascariensis extracts showed strong antimalarial activity against Plasmodium falciparum (13). Compounds isolated from the roots of Salacia kraussii exhibited antimalarial activity against blood stages of Plasmodium berghei (14). AntineoplasticsAntineoplastics: Salacia campestris synthesized quinonemethide triterpenoids, thought to have antitumoral properties (15). An extract from Salacia oblonga showed cytotoxicity against Ehrlich ascites tumor cells in vitro (16). A salacinol analog inhibited Drosophila melanogaster Golgi mannosidase II in vitro, indicating a potential for antimetastatic effects (17). Antiobesity herbs and supplementsAntiobesity herbs and supplements: In animal research, Salacia oblonga or Salacia reticulata extract caused a reduction in visceral fat mass, body weight, and feed intake (34; 35). AntioxidantsAntioxidants: In animal research, Salacia oblonga extract and a Salacia chinensis stem extract exhibited radical-scavenging activities (21; 18; 22; 23). In vitro, constituents isolated from Salacia reticulata, Salacia campestris, and the stems of Salacia chinensis exhibited radical-scavenging activity (19; 20; 24; 25). AntiparasiticsAntiparasitics: Constituents isolated from the extract of the roots of Salacia madagascariensis showed potent activity against Leishmania (26). Cardiovascular herbs and supplementsCardiovascular herbs and supplements: In diabetic rats, Salacia oblonga root inhibited cardiac fatty acid oxidation, reduced cardiac triglyceride and fatty acid in the myocardium, and decreased cardiac hypertrophy and fibrosis (27; 28; 29). HypoglycemicsHypoglycemics: In patients with type 2 diabetes and in healthy humans who took Salacia reticulata tea or Salacia oblonga extract, there was a significant decrease in the postprandial glucose and insulin responses (42; 40; 41; 43). Similar effects were noted in animal and in vitro studies (44; 9; 45; 46; 47; 18; 48; 49; 50; 51; 21; 52; 22; 23; 53; 54; 16; 55). Salacia/Food Interactions:
Insufficient available evidence.Salacia/Lab Interactions:
Body weightBody weight: In animal research, Salacia oblonga or Salacia reticulata extract caused a reduction in visceral fat mass and body weight (34; 35; 31). Glucose levelsGlucose levels: In patients with type 2 diabetes and in healthy humans who took Salacia reticulata tea or Salacia oblonga extract, there was a significant decrease in the postprandial glucose response (42; 40; 41; 43). Similar effects were noted in animal and in vitro studies (44; 9; 45; 46; 47; 18; 48; 49; 50; 51; 21; 52; 22; 23; 53; 54; 16; 55). Insulin levelsInsulin levels: In patients with type 2 diabetes and in healthy humans who took Salacia reticulata tea or Salacia oblonga extract, there was a significant decrease in the postprandial insulin response (42; 40; 41; 43). Similar effects were noted in animal and in vitro studies (44; 9; 45; 46; 47; 18; 48; 49; 50; 51; 21; 52; 22; 23; 53; 54; 16; 55). Lipid levelsLipid levels: In obese rats, oral administration of Salacia oblonga root extract lowered plasma triglyceride and total cholesterol levels, increased plasma high-density lipoprotein levels, and reduced liver triglyceride, nonesterified fatty acids, and the ratio of fatty droplets to total tissue (30).