Sarsaparilla

Sarsaparilla/Drug Interactions:

  • AntifungalsAntifungals: Based on in vitro study, steroidal saponins isolated from the roots of Smilax medica may have weak antifungal activity against Candida albicans, Candida glabrata, and Candida tropicalis (4).
  • AntineoplasticsAntineoplastics: Based on animal study, extracts of sarsaparilla and its constituents may have cytotoxic and immunosuppressive activity (1; 12; 13).
  • AntiviralsAntivirals: Based on in vitro study, smilaxin purified from sarsaparilla rhizomes may attenuate the activity of HIV-1-reverse transcriptase (12).
  • HepatotoxinsHepatotoxins: Based on mouse studies, astilbin isolated from Smilacis glabrae rhizome may improve T cell-mediated liver injury (17).
  • ImmunosuppressantsImmunosuppressants: Based on in vitro study, extracts of Smilacis glabrae rhizoma may have antiarthritic activity via selected suppression of lymphocyte functions, macrophages, and bone marrow cells (7; 12).

    • Sarsaparilla/Herb/Supplement Interactions:

  • AntifungalsAntifungals: Based on in vitro study, steroidal saponins isolated from the roots of Smilax medica may have weak antifungal activity against Candida albicans, Candida glabrata, and Candida tropicalis (4).
  • AntineoplasticsAntineoplastics: Based on animal study, extracts of sarsaparilla and its constituents may have cytotoxic and immunosuppressive activity (1; 12; 13).
  • AntiviralsAntivirals: Based on in vitro study, smilaxin purified from sarsaparilla rhizomes may attenuate the activity of HIV-1-reverse transcriptase (12).
  • HepatotoxinsHepatotoxins: Based on mouse studies, astilbin isolated from Smilacis glabrae rhizome may improve T cell-mediated liver injury (17).
  • ImmunosuppressantsImmunosuppressants: Based on in vitro study, extracts of Smilacis glabrae rhizoma may have antiarthritic activity via selected suppression of lymphocyte functions, macrophages, and bone marrow cells (7; 12).

    • Sarsaparilla/Food Interactions:

  • Insufficient available evidence.

    • Sarsaparilla/Lab Interactions:

  • HIV viral loadHIV viral load: Based on in vitro study, smilaxin purified from sarsaparilla rhizomes may attenuate the activity of HIV-1-reverse transcriptase (12).
  • Liver panelLiver panel: Based on mouse studies, astilbin isolated from Smilacis glabrae rhizome may improve T cell-mediated liver injury (17).
  • White blood cell (WBC) counts and differentialWhite blood cell (WBC) counts and differential: Based on in vitro and animal study, extracts of sarsaparilla and its constituents may have cytotoxic and immunomodulatory effects as well as effects on macrophages and bone marrow cells (7; 12; 13; 1).