Sassafras

Sassafras/Drug Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study, the aryl-sulfonamide compounds found in safrole may induce platelet aggregation (5).
  • Cytochrome P450 metabolized agentsCytochrome P450 metabolized agents: Based on an in vitro study, safrole may be a potent inhibitor of CYP1A2, CYP2A6, and CYP2E1, and may inhibit CYP2D6 and CYP3A4 to a lesser degree (4).

    • Sassafras/Herb/Supplement Interactions:

  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an in vitro study, the aryl-sulfonamide compounds found in safrole may induce platelet aggregation (5).
  • Cytochrome P450 metabolized herbs and supplementsCytochrome P450 metabolized herbs and supplements: Based on an in vitro study, safrole may be a potent inhibitor of CYP1A2, CYP2A6, and CYP2E1, and may inhibit CYP2D6 and CYP3A4 to a lesser degree (4).

    • Sassafras/Food Interactions:

  • Insufficient available evidence.

    • Sassafras/Lab Interactions:

  • Coagulation panelCoagulation panel: Based on an in vitro study, the aryl-sulfonamide compounds found in safrole may induce platelet aggregation (5).
  • Serum levels of cytochrome P450 metabolized drugs or herbsSerum levels of cytochrome P450 metabolized drugs or herbs: Based on an in vitro study, safrole may be a potent inhibitor of CYP1A2, CYP2A6, and CYP2E1, and may inhibit CYP2D6 and CYP3A4 to a lesser degree (4).