Siberian cocklebur

Siberian cocklebur/Drug Interactions:

  • AntibioticsAntibiotics: In in vitro studies, Siberian cocklebur has been shown to exhibit antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (1).
  • Antidiabetic agentsAntidiabetic agents: In a case study of a 20 month-old girl, administration of Siberian cocklebur caused hypoglycemia (7).
  • Anti-inflammatory agentsAnti-inflammatory agents: In in vitro research, Siberian cocklebur (fructus Xanthii) has been shown to inhibit interferon (IFN)-gamma and lipopolysaccharide-induced nitric oxide (NO) synthase protein production in a dose-dependent manner (2).
  • ImmunosuppressantsImmunosuppressants: In in vitro research, Siberian cocklebur (fructus Xanthii) has been shown to modulate mast cell-mediated and peripheral blood mononuclear cell (PBC)-mediated inflammatory and immunological reactions modulated by cytokines (10).

    • Siberian cocklebur /Herb/Supplement Interactions:

  • Antibacterial herbs and supplementsAntibacterial herbs and supplements: In in vitro studies, Siberian cocklebur has been shown to exhibit antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) (1).
  • Anti-inflammatory agentsAnti-inflammatory agents: In in vitro research, Siberian cocklebur (fructus Xanthii) has been shown to inhibit interferon (IFN)-gamma and lipopolysaccharide-induced nitric oxide (NO) synthase protein production in a dose-dependent manner (2).
  • Herbs and supplements with potential immunomodulating activityHerbs and supplements with potential immunomodulating activity: In in vitro research, Siberian cocklebur (fructus Xanthii) has been shown to modulate mast cell-mediated and peripheral blood mononuclear cell (PBC)-mediated inflammatory and immunological reactions modulated by cytokines (10).
  • HypoglycemicsHypoglycemics: In a case study of a 20 month-old girl, administration of Siberian cocklebur caused hypoglycemia (7).

    • Siberian cocklebur/Food Interactions:

  • Insufficient available evidence.

    • Siberian cocklebur /Lab Interactions:

  • GlucoseGlucose: In a case study of a 20 month-old girl, administration of Siberian cocklebur caused hypoglycemia (7).
  • Liver function testsLiver function tests: According to secondary sources, use of Siberian cocklebur resulted in elevation of alanine aminotransferase, aspartate aminotransferase, ammonia, and bilirubin. These are predictive markers of liver function. The elevation of alanine aminotransferase, aspartate aminotransferase, ammonia, and bilirubin suggest hepatic failure.