Silica

Silicon/Drug Interactions:

  • 5-Aminosalicylic acid5-Aminosalicylic acid: An animal study reported that concomitant administration of 70nm silica particles (nSP70) and 5-aminosalicylic acid increased hepatotoxicity in mice (58).
  • AcetaminophenAcetaminophen: An animal study reported that concomitant administration of nSP70 and acetaminophen increased hepatotoxicity in mice (58).
  • AluminumAluminum: Animal studies and limited human research suggest that dietary silicon may affect aluminum bioavailability, limit aluminum absorption, and alter urinary excretion of dietary aluminum (6; 2; 67; 68; 69). Animal studies also suggest that dietary silicon may protect against aluminum accumulation in tissues, although conflicting findings have been reported (6; 2; 67; 68; 70).
  • Drugs used for osteoporosisDrugs used for osteoporosis: Human research has shown that increased dietary intake of silicon is statistically significantly associated with increased bone mineral density (BMD) in men, premenopausal women, and postmenopausal women taking hormone replacement therapy (1; 11). Other human studies have demonstrated an association between silicon intake and trabecular bone volume and BMD in osteoporotic subjects and between markers of bone formation and BMD in women with low bone mass (12; 13; 14).
  • IronIron: According to review data, silicon in the form of silicic acid interacted weakly with ferric iron at physiological pH (2). According to preliminary research, the pathways of silicon and iron metabolism may be directly linked (71).
  • TetracyclineTetracycline: An animal study reported that concomitant administration of nSP70 and tetracycline produced a lethal effect in mice (58).

    • Silicon/Herb/Supplement Interactions:

  • AluminumAluminum: Animal studies and limited human research suggest that dietary silicon may affect aluminum bioavailability, limit aluminum absorption, and alter urinary excretion of dietary aluminum (6; 2; 67; 68; 69). Animal studies also suggest that dietary silicon may protect against aluminum accumulation in tissues, although conflicting findings have been reported (6; 2; 67; 68; 70).
  • GermaniumGermanium: Germanium (Ge) reversed changes in rats caused by silicon deprivation (3). Further details are lacking.
  • IronIron: According to review data, silicon in the form of silicic acid interacted weakly with ferric iron at physiological pH (2). According to preliminary research, the pathways of silicon and iron metabolism may be directly linked (71).
  • Osteoporosis agentsOsteoporosis agents: Human research has shown that increased dietary intake of silicon is statistically significantly associated with increased bone mineral density in men, premenopausal women, and postmenopausal women taking hormone replacement therapy (1; 11). Other human studies have demonstrated an association between silicon intake and trabecular bone volume and BMD in osteoporotic subjects and between markers of bone formation and BMD in women with low bone mass (12; 13; 14).

    • Silicon/Food Interactions:

  • Insufficient available evidence.

    • Silicon/Lab Interactions:

  • Serum and urinary aluminumSerum and urinary aluminum: Animal studies and limited human research suggest that dietary silicon may affect aluminum bioavailability, limit aluminum absorption, and alter urinary excretion of dietary aluminum (6; 2; 67; 68; 69).
  • Serum ironSerum iron: Silicon in the form of silicic acid interacted weakly with ferric iron at physiological pH (2). According to preliminary research, the pathways of silicon and iron metabolism may be directly linked (71).