Squill

Squill/Drug Interactions:

  • CalciumCalcium: Concomitant use of calcium may increase risk of cardiac toxicity, theoretically.
  • Cardiac glycosides (Digoxin, Digitoxin)Cardiac glycosides (Digoxin, Digitoxin): Urginea maritima contains cardiokinetic 3-beta-ramnoside-14-beta-hydroxy-delta-4,20,22-bufatrienolide (proscillaridine A) (8) and it has shown similar toxic effects to cardiac glycoside toxicity (5). In theory, squill may have additive toxic effects when used with cardiac glycosides.
  • CorticosteroidsCorticosteroids: Concomitant use may increase effects and adverse effects of long-term corticosteroid use, theoretically.
  • DiureticsDiuretics: In theory, due to potassium depletion caused by some diuretics, the risk of cardiac toxicity may be increased with concurrent use. Historical texts document squill's diuretic effects (1; 2).
  • LaxativesLaxatives: Due to potassium depletion caused by some laxatives, the risk of cardiac toxicity may be increased with concomitant use (theoretical).
  • Potassium depleting diureticsPotassium depleting diuretics: In theory, due to potassium depletion caused by some diuretics, the risk of cardiac toxicity from squill may be increased with concurrent use.
  • QuinidineQuinidine: Concomitant use may increase the risk of cardiac and adverse effects, theoretically.

    • Squill/Herb/Supplement Interactions:

  • CalciumCalcium: Concomitant use of calcium may increase risk of cardiac toxicity, theoretically.
  • Cardiac glycoside containing herbsCardiac glycoside containing herbs: A number of other plant species have been found to contain cardiac glycosides or demonstrate cardiac glycoside activity. Theoretically, because squill contains a cardiokinetic 3-beta-ramnoside-14-beta-hydroxy-delta-4,20,22-bufatrienolide (proscillaridine A) (8), and has also shown similar toxic effects to cardiac glycoside toxicity (5), ingestion of these species concomitantly with squill may augment effects and toxicity.
  • DiureticsDiuretics: In theory, due to potassium depletion caused by some diuretics, the risk of cardiac toxicity may be increased with concurrent use.
  • LaxativesLaxatives: In theory, due to potassium depletion caused by some laxative agents, the risk of cardiac toxicity may be increased with combination use.
  • LicoriceLicorice: In theory, due to potassium depletion, the risk of cardiac toxicity may be increased with combination use.

    • Squill/Food Interactions:

  • Insufficient available evidence.

    • Squill/Lab Interactions:

  • PotassiumPotassium: Squill may lower serum potassium levels, in theory.