Vanadium

Vanadium/Drug Interactions:

  • AnticoagulantsAnticoagulants: According to a review, vanadium may have anticoagulant effects (12).
  • Antidiabetic agentsAntidiabetic agents: The antidiabetic effects of vanadium compounds have been reviewed (104; 105; 106; 107; 108; 109). In vitro, vanadium and various vanadium compounds, including organovanadium compounds (OVC), such as bis(maltolato)oxovanadium(IV), may act as an insulin mimetic and improve glycemic control (43; 44; 45; 11; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 44; 62; 63). Orally active metal complexes containing vanadium have demonstrated antidiabetic activity in animal studies (21).
  • AntihypertensivesAntihypertensives: In spontaneously hypertensive rats consuming a high-sucrose diet, vanadium reversed increases in angiotensin II, possibly through an increase in endothelin-1 levels (64). Based on a review, vanadium may be beneficial in primary arterial hypertension (65).
  • AntilipemicsAntilipemics: According to review data, pharmacologic amounts of vanadium (approximately 10-100 times the normal intake for Americans, estimated to be 10-60mcg daily, based on a food intake of 500g dry weight) may affect cholesterol and triglyceride metabolism in humans (103).
  • AntineoplasticsAntineoplastics: According to a review, vanadium may have antineoplastic effects (12). In animals, supplementation with vanadium, in the form of ammonium metavanadate, exerted an antihepatocarcinogenic effect (15). However, vanadium may exert carcinogenic effects via production of reactive oxygen species (ROS) (71). Vanadium may also stimulate expression of protooncogenes (56).
  • AntiviralsAntivirals: According to a review, vanadium may have antiviral effects (12).
  • Cardiovascular agentsCardiovascular agents: Based on a review, environmental exposure to vanadium may be associated with an increased risk of cardiopulmonary disease (66; 67).
  • Cytochrome P450 substratesCytochrome P450 substrates: According to a review, vanadium may exert effects on CYP1A1 enzyme activity (110).
  • ImmunostimulantsImmunostimulants: Vanadium may regulate immunological responses (111). Based on a review, immunotoxicity has been reported following exposure to vanadium compounds (68).
  • ImmunosuppressantsImmunosuppressants: Vanadium may regulate immunological responses (111). Based on a review, immunotoxicity has been reported following exposure to vanadium compounds (68).
  • NephrotoxicsNephrotoxics: According to secondary sources, ingestion of vanadium pentoxide may cause significant renal toxicity. According to a review, at higher intakes, vanadium may accumulate in kidney tissue (39). High levels of vanadium may be associated with an increased incidence of renal stone disease, distal renal tubular acidosis, and hypokalemic periodic paralysis, according to secondary sources. Increased serum urea and creatinine levels may occur. According to a review, vanadate has been suggested as being involved in the pathogenesis of "uremic syndrome" and acquired cystic kidney disease (70). Based on a review, nephrotoxicity has been reported following exposure to vanadium compounds (68).
  • Neurologic agentsNeurologic agents: Based on a review, behavioral toxicity has been reported following exposure to vanadium compounds (68). Based on a review, raised plasma levels of vanadium have been reported in patients with manic depression (69). According to a review, vanadate has been suggested as being involved in the pathogenesis of depression (70).

    • Vanadium/Herb/Supplement Interactions:

  • AnticoagulantsAnticoagulants: According to a review, vanadium may have anticoagulant effects (12).
  • AntilipemicsAntilipemics: According to review data, pharmacologic amounts of vanadium (approximately 10-100 times the normal intake for Americans, estimated to be 10-60mcg daily, based on a food intake of 500g dry weight) may affect cholesterol and triglyceride metabolism in humans (103).
  • AntineoplasticsAntineoplastics: According to a review, vanadium may have antineoplastic effects (12). In animals, supplementation with vanadium, in the form of ammonium metavanadate, exerted an antihepatocarcinogenic effect (15). However, vanadium may exert carcinogenic effects via production of ROS (71). Vanadium may also stimulate expression of protooncogenes (56).
  • AntiviralsAntivirals: According to a review, vanadium may have antiviral effects (12).
  • Cardiovascular agentsCardiovascular agents: Based on a review, environmental exposure to vanadium may be associated with an increased risk of cardiopulmonary disease (66; 67).
  • Cytochrome P450 substratesCytochrome P450 substrates: According to a review, vanadium may exert effects on CYP1A1 enzyme activity (110).
  • HypoglycemicsHypoglycemics: The antidiabetic effects of vanadium compounds have been reviewed (112; 105; 106; 107; 108; 109). In vitro, vanadium and various vanadium compounds, including organovanadium compounds (OVC), such as bis(maltolato)oxovanadium(IV), may act as an insulin mimetic and improve glycemic control (43; 44; 45; 11; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 44; 62; 63). Orally active metal complexes containing vanadium have demonstrated antidiabetic activity in animal studies (21).
  • HypotensivesHypotensives: In spontaneously hypertensive rats consuming a high-sucrose diet, vanadium reversed increases in angiotensin II, possibly through an increase in endothelin-1 levels (64). Based on a review, vanadium may be beneficial in primary arterial hypertension (65).
  • ImmunomodulatorsImmunomodulators: Vanadium may regulate immunological responses (111). Based on a review, immunotoxicity has been reported following exposure to vanadium compounds (68).
  • NephrotoxicsNephrotoxics: According to secondary sources, ingestion of vanadium pentoxide may cause significant renal toxicity. According to a review, at higher intakes, vanadium may accumulate in kidney tissue (39). High levels of vanadium may be associated with an increased incidence of renal stone disease, distal renal tubular acidosis, and hypokalemic periodic paralysis, according to secondary sources. Increased serum urea and creatinine levels may occur. According to a review, vanadate has been suggested as being involved in the pathogenesis of "uremic syndrome" and acquired cystic kidney disease (70). Based on a review, nephrotoxicity has been reported following exposure to vanadium compounds (68).
  • Neurological herbs and supplementsNeurological herbs and supplements: Based on a review, behavioral toxicity has been reported following exposure to vanadium compounds (68). Based on a review, raised plasma levels of vanadium have been reported in patients with manic depression (69). According to a review, vanadate has been suggested as being involved in the pathogenesis of depression (70).
  • SeleniumSelenium: According to a review, selenium may counteract the neurotoxic effects of various metals, including vanadium (113).

    • Vanadium/Food Interactions:

  • Insufficient available evidence.

    • Vanadium/Lab Interactions:

  • Blood pressureBlood pressure: In spontaneously hypertensive rats consuming a high-sucrose diet, vanadium reversed increases in angiotensin II, possibly through an increase in endothelin-1 levels (64). Based on a review, vanadium may be beneficial in primary arterial hypertension (65).
  • Blood sugarBlood sugar: The antidiabetic effects of vanadium compounds have been reviewed (104; 105; 106; 107; 108; 109). In vitro, vanadium and various vanadium compounds, including organovanadium compounds (OVC), such as bis(maltolato)oxovanadium(IV), may act as an insulin mimetic and improve glycemic control (43; 44; 45; 11; 46; 47; 48; 49; 50; 51; 52; 53; 54; 55; 56; 57; 58; 59; 60; 61; 44; 62; 63). Orally active metal complexes containing vanadium have demonstrated antidiabetic activity in animal studies (21).
  • Coagulation panelCoagulation panel: According to a review, vanadium may have anticoagulant effects (12).
  • Lipid panelLipid panel: According to review data, pharmacologic amounts of vanadium (approximately 10-100 times normal intake for Americans, estimated to be 10-60mcg daily based on a food intake of 500g dry weight) may affect cholesterol and triglyceride metabolism in humans (103).