Wasabi

Wasabi/Drug Interactions:

  • Analgesics, topicalAnalgesics, topical: Based on in vitro study, topical wasabi may produce pain and activate the same neurons as topical analgesics, especially capsaicin-based analgesics (13; 9; 10).
  • AntibioticsAntibiotics: Based on laboratory study, all parts of the wasabi plant may have antibiotic activity (11).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vivo study in animals, wasabi may inhibit platelet aggregation (6; 7).
  • Antiinflammatory agentsAntiinflammatory agents: Based on in vitro study, wasabi may inhibit COX-1 enzyme activity (5).
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro study, several constituents have shown anticancer activity (1; 2; 3; 6; 7; 5). However, desulfosinigrin isolated from a commercially available wasabi powder and from fresh wasabi roots promoted the growth of human colon (HCT-116) and lung (NCIH460) cancer cells in a concentration-dependent manner (4).
  • Antiulcer agentsAntiulcer agents: Based on laboratory study, all parts of the wasabi plant may have anti-H. pylori activity (11).
  • BisphosphonatesBisphosphonates: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • EstrogensEstrogens: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Estrogen and progestin combinationEstrogen and progestin combination: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Hepatotoxic agentsHepatotoxic agents: Based on in vitro and in vivo study, wasabi may induce glutathione S-transferase (GST) activity (6; 7).
  • Hormonal agentsHormonal agents: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Liver-metabolized agentsLiver-metabolized agents: Based on in vitro and in vivo study, wasabi may induce glutathione S-transferase (GST) activity (6; 7).
  • Selective estrogen receptor modifiers (SERMs)Selective estrogen receptor modifiers (SERMs): Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).

    • Wasabi/Herb/Supplement Interactions:

  • AntibacterialsAntibacterials: Based on laboratory study, all parts of the wasabi plant may have antibacterial activity (11).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on in vivo study in animals, wasabi may inhibit platelet aggregation (6; 7).
  • Anti inflammatory herbsAnti inflammatory herbs: Based on in vitro study, wasabi may inhibit COX-1 enzyme (5).
  • AntineoplasticsAntineoplastics: Based on in vitro study, several constituents have shown anticancer activity (1; 2; 3; 6; 7; 5). However, desulfosinigrin isolated from a commercially available wasabi powder and from fresh wasabi roots promoted the growth of human colon (HCT-116) and lung (NCIH460) cancer cells in a concentration-dependent manner (4).
  • Anti-osteoporosis agentsAnti-osteoporosis agents: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Antiulcer agentsAntiulcer agents: Based on laboratory study, all parts of the wasabi plant may have anti-H. pylori activity (11).
  • Cannabis sativaCannabis sativa: Based on in vitro study, topical wasabi may produce pain and activate the same neurons as delta(9)-tetrahydrocannabinol (THC), the psychoactive component found in Cannabis sativa (13; 9; 10).
  • CapsaicinCapsaicin: Based on in vitro study, topical wasabi may produce pain and activate the same neurons as capsaicin (13; 9; 10).
  • Hepatotoxic herbsHepatotoxic herbs: Based on in vitro and in vivo study, wasabi may induce glutathione S-transferase (GST) activity (6; 7).
  • Hormonal herbs and supplementsHormonal herbs and supplements: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Liver-metabolized agentsLiver-metabolized agents: Based on in vitro and in vivo study, wasabi may induce glutathione S-transferase (GST) activity (6; 7).
  • PhytoestrogensPhytoestrogens: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).

    • Wasabi/Food Interactions:

  • Capsaicin-containing foodsCapsaicin-containing foods: Based on in vitro study, topical wasabi may produce pain and activate the same neurons as capsaicin (13; 9; 10).

    • Wasabi/Lab Interactions:

  • Bone densityBone density: Extracts from wasabi leafstalk (Wasabi japonica Matsum) may have an anabolic effect on bone metabolism (8).
  • Coagulation panelCoagulation panel: Based on in vivo study in animals, wasabi may inhibit platelet aggregation (6; 7).
  • H. pylori testsH. pylori tests: Based on laboratory study, all parts of the wasabi plant may have anti-H. pylori activity (11).
  • Serum levels of liver-metabolized agentsSerum levels of liver-metabolized agents: Based on in vitro and in vivo study, wasabi may induce glutathione S-transferase (GST) activity (6; 7).