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Hormonal Agents
Hormonal Agents/Nutrient Depletion:
Calcium
Calcium: Based on human evidence, hormone replacement therapy (HRT) alone (as piperazine estrone sulfate ? medroxyprogesterone acetate) may be associated with a fall in calcium absorption efficiency (
8845601
). The bone preserving effects of estrogen treatment may be increased by calcium supplementation. Estrogen generally increases supplemental calcium absorption in postmenopausal women.
Melatonin
Melatonin: Based on human and animal evidence, medications, such as hormone replacement therapy, that reduce levels of vitamin B6 in the body may also deplete melatonin levels (
8872867
,
272672
). Based on human evidence, somatostatin may alter synthesis or release of melatonin (
10475150
). Based on human evidence, hormone replacement therapy is reported to cause a decrease in daily melatonin secretion without disturbing circadian rhythm (
12080285
,
12080286
).