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Curcuma longa
Turmeric/Nutrient Depletion:
Glucose
Glucose: Curcumin was found to decrease blood sugar in a diabetic patient (
258
). In an animal study, turmeric extracts exhibited hypoglycemic effects in type 2 diabetic mice (
267
). Administration of tetrahydrocurcumin and curcumin to diabetic rats resulted in decreased levels of blood glucose (
506
).
Iron
Iron: In vitro research has suggested that curcumin may be an effective iron chelator (
285
;
286
). Turmeric has been found to inhibit and reduce iron availability in a dose-dependent manner (
287
). In animal research, curcumin induced a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation; the appearance of microcytic anisocytotic red blood cells; and decreases in spleen and liver iron content (
288
). However, in human research, turmeric did not inhibit iron absorption (
289
).
Lipids
Lipids: Hypolipidemic effects of curcumin have been shown in animal research (
521
;
522
;
319
;
518
;
523
;
524
;
519
;
520
;
525
;
526
).
Vitamin A
Vitamin A: In in vitro research, curcumin inhibited beta-carotene-15,15'-dioxygenase activity, the enzyme responsible for providing vertebrates with vitamin A (
829
).