L-methionine

Methionine/Nutrient Depletions:

  • Antineoplastic agentsAntineoplastic agents: In mice, methionine depletion increased the efficacy of cisplatin against the MX-t human breast carcinoma cell line (11) and significantly enhanced the antitumor activity of 5-fluorouracil against the SC-1-NU human gastric cancer xenograft by approximately twofold (12). Synergy between methionine restriction and 5-fluorouracil may be attributable to multiple factors, including depletion of reduced folates, selective inhibition of thymidylate synthase, and creation of an imbalanced nucleotide pool (26).