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Lignans
Lignan/Nutrient Depletion:
Cholesterol
Cholesterol: In human and animal research, lignans like sesamin treatment significantly reduced total cholesterol, LDL cholesterol, and apoprotein B (
110
;
83
;
109
;
36
).
Glucose
Glucose: In humans, treatment with CPH 82 (Reumacon?), a purified semisynthetic lignan glycoside derivative of the medicinal herb Podophyllum emodi, resulted in a decrease in serum glucose (
84
).
Sodium
Sodium: Based on a rat study, the lignan elenoside may have an antidiuretic effect and decrease sodium excretion (
44
).
Vitamin E
Vitamin E: Based on in vitro and clinical studies, ingestion of the lignan sesamin may significantly reduce the metabolism of vitamin E and decrease serum and urinary levels of its metabolites (
167
;
87
).