Manganese

Manganese/Nutrient Depletion:

  • GeneralGeneral: Manganese deficiency may lead to digestive system diseases (520).
  • AntacidsAntacids: According to secondary sources, antacids may interfere with manganese absorption.
  • Calcium saltsCalcium salts: The addition of calcium to human milk significantly decreased manganese absorption (481).
  • FatFat: In human research, low-fat diets inhibited the absorption of manganese (504).
  • IronIron: In young sportsmen, iron-containing supplements decreased plasma manganese concentrations (521).
  • MineralsMinerals: According to secondary sources, high intakes of magnesium, calcium, phosphorus, iron, copper, and zinc may inhibit the absorption of manganese.
  • Phytic acidPhytic acid: According to secondary sources, phytic acid may inhibit the absorption of manganese (499).
  • Ursodeoxycholic acid therapy (UDCA)Ursodeoxycholic acid therapy (UDCA): In patients with intrahepatic cholestatic liver disease, UDCA produced a significant decrease in manganese levels (522).
  • VitaminsVitamins: The addition of vitamins (ascorutin, thiamin, riboflavin, pyridoxine, cyanocobalamin, and folic acid) to the diet may result in an increase in intestinal and urinary excretion of manganese (523).
  • ZincZinc: According to secondary sources, high doses of manganese may inhibit the absorption of zinc. Zinc may affect manganese tissue levels (503).